Protein nutrition governs within-host race of honey bee pathogens

Abstract Multiple infections are common in honey bees, Apis mellifera, but the possible role of nutrition in this regard is poorly understood. Microsporidian infections, which are promoted by protein-fed, can negatively correlate with virus infections, but the role of protein nutrition for the micro...

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Autores principales:	Manuel Tritschler, Jutta J. Vollmann, Orlando Yañez, Nor Chejanovsky, Karl Crailsheim, Peter Neumann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2bf16b265cb74e3e96070233b57d9b7f
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spelling	oai:doaj.org-article:2bf16b265cb74e3e96070233b57d9b7f2021-12-02T11:41:01ZProtein nutrition governs within-host race of honey bee pathogens10.1038/s41598-017-15358-w2045-2322https://doaj.org/article/2bf16b265cb74e3e96070233b57d9b7f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-15358-whttps://doaj.org/toc/2045-2322Abstract Multiple infections are common in honey bees, Apis mellifera, but the possible role of nutrition in this regard is poorly understood. Microsporidian infections, which are promoted by protein-fed, can negatively correlate with virus infections, but the role of protein nutrition for the microsporidian-virus interface is unknown. Here, we challenged naturally deformed wing virus - B (DWV-B) infected adult honey bee workers fed with or without pollen ( = protein) in hoarding cages, with the microsporidian Nosema ceranae. Bee mortality was recorded for 14 days and N. ceranae spore loads and DWV-B titers were quantified. Amongst the groups inoculated with N. ceranae, more spores were counted in protein-fed bees. However, N. ceranae infected bees without protein-diet had reduced longevity compared to all other groups. N. ceranae infection had no effect on protein-fed bee’s longevity, whereas bees supplied only with sugar-water showed reduced survival. Our data also support that protein-feeding can have a significant negative impact on virus infections in insects. The negative correlation between N. ceranae spore loads and DWV-B titers was stronger expressed in protein-fed hosts. Proteins not only enhance survival of infected hosts, but also significantly shape the microsporidian-virus interface, probably due to increased spore production and enhanced host immunity.Manuel TritschlerJutta J. VollmannOrlando YañezNor ChejanovskyKarl CrailsheimPeter NeumannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manuel Tritschler Jutta J. Vollmann Orlando Yañez Nor Chejanovsky Karl Crailsheim Peter Neumann Protein nutrition governs within-host race of honey bee pathogens
description	Abstract Multiple infections are common in honey bees, Apis mellifera, but the possible role of nutrition in this regard is poorly understood. Microsporidian infections, which are promoted by protein-fed, can negatively correlate with virus infections, but the role of protein nutrition for the microsporidian-virus interface is unknown. Here, we challenged naturally deformed wing virus - B (DWV-B) infected adult honey bee workers fed with or without pollen ( = protein) in hoarding cages, with the microsporidian Nosema ceranae. Bee mortality was recorded for 14 days and N. ceranae spore loads and DWV-B titers were quantified. Amongst the groups inoculated with N. ceranae, more spores were counted in protein-fed bees. However, N. ceranae infected bees without protein-diet had reduced longevity compared to all other groups. N. ceranae infection had no effect on protein-fed bee’s longevity, whereas bees supplied only with sugar-water showed reduced survival. Our data also support that protein-feeding can have a significant negative impact on virus infections in insects. The negative correlation between N. ceranae spore loads and DWV-B titers was stronger expressed in protein-fed hosts. Proteins not only enhance survival of infected hosts, but also significantly shape the microsporidian-virus interface, probably due to increased spore production and enhanced host immunity.
format	article
author	Manuel Tritschler Jutta J. Vollmann Orlando Yañez Nor Chejanovsky Karl Crailsheim Peter Neumann
author_facet	Manuel Tritschler Jutta J. Vollmann Orlando Yañez Nor Chejanovsky Karl Crailsheim Peter Neumann
author_sort	Manuel Tritschler
title	Protein nutrition governs within-host race of honey bee pathogens
title_short	Protein nutrition governs within-host race of honey bee pathogens
title_full	Protein nutrition governs within-host race of honey bee pathogens
title_fullStr	Protein nutrition governs within-host race of honey bee pathogens
title_full_unstemmed	Protein nutrition governs within-host race of honey bee pathogens
title_sort	protein nutrition governs within-host race of honey bee pathogens
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2bf16b265cb74e3e96070233b57d9b7f
work_keys_str_mv	AT manueltritschler proteinnutritiongovernswithinhostraceofhoneybeepathogens AT juttajvollmann proteinnutritiongovernswithinhostraceofhoneybeepathogens AT orlandoyanez proteinnutritiongovernswithinhostraceofhoneybeepathogens AT norchejanovsky proteinnutritiongovernswithinhostraceofhoneybeepathogens AT karlcrailsheim proteinnutritiongovernswithinhostraceofhoneybeepathogens AT peterneumann proteinnutritiongovernswithinhostraceofhoneybeepathogens
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Protein nutrition governs within-host race of honey bee pathogens

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