Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines

Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines

Ralph Victor Yap, Frances Marion De La Serna Department of Surgery, Cebu Doctors’ University Hospital, Cebu City, Cebu, PhilippinesCorrespondence: Ralph Victor YapDepartment of Surgery, Cebu Doctors’ University Hospital, Osmeña Boulevard, Cebu City 6000, Cebu, Philippi...

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Autores principales: Yap RV, De La Serna FM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
breast cancer
philippines
slnb
outcomes
sentinel
blue dye
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/2bf4cd8dbb524f0d9a39af9accb31210
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spelling oai:doaj.org-article:2bf4cd8dbb524f0d9a39af9accb312102021-12-02T11:05:34ZOutcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines1179-1314https://doaj.org/article/2bf4cd8dbb524f0d9a39af9accb312102020-03-01T00:00:00Zhttps://www.dovepress.com/outcomes-of-sentinel-lymph-node-biopsy-using-blue-dye-method-for-early-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Ralph Victor Yap, Frances Marion De La Serna Department of Surgery, Cebu Doctors’ University Hospital, Cebu City, Cebu, PhilippinesCorrespondence: Ralph Victor YapDepartment of Surgery, Cebu Doctors’ University Hospital, Osmeña Boulevard, Cebu City 6000, Cebu, PhilippinesTel +63 917 130 1923Fax +63 32 255 5555Email rvyapmd@gmail.comPurpose: This study aimed to share our experience with SLNB in the Filipino population with early breast cancer.Patients and Methods: A retrospective review was done on all patients with confirmed invasive breast carcinoma, tumor size of 5 cm or less (T1/T2), who preoperatively had no clinical signs of axillary metastasis and subsequently underwent SLNB with blue dye method from January 01, 2008 to December 31, 2017. Clinicopathologic profiles were recorded. Outcomes of patients who had SLNB only were assessed.Results: One hundred twenty-nine patients matched the inclusion criteria with a mean age of 54.3 years. The majority (88.4%) had a total mastectomy. Invasive ductal carcinoma (65.1%) was the most common tumor. Estrogen and progesterone receptors were positive in 69% and 61.2% respectively while only 28.7% were HER2 positive. SLNB was successfully carried out in 126 (97.7%) patients with a range of 2– 4 SLNs harvested. Thirty-four (26.4%) patients had completion ALND. With a median of 25 months follow-up, 75 out of 95 patients who underwent SLNB alone had follow-up data. Forty-six (61.3%) patients had seroma formation. One (1.3%) patient developed arm paresthesia, 2 (2.7%) local (chest wall) and 2 (2.7%) axillary recurrences after a negative SLNB. None of the patients developed lymphedema.Conclusion: The blue dye method alone is acceptable and can be readily employed in institutions with limited resources. Even with the limited population, the morbidity and oncologic outcomes of patients who underwent SLNB alone were low and comparable to similar international published data. SLNB should be the preferred method for staging the axilla.Keywords: breast cancer, Philippines, SLNB, outcomes, sentinel, blue dyeYap RVDe La Serna FMDove Medical Pressarticlebreast cancerphilippinesslnboutcomessentinelblue dyeNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 12, Pp 37-44 (2020)
institution DOAJ
collection DOAJ
language EN
topic breast cancer
philippines
slnb
outcomes
sentinel
blue dye
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle breast cancer
philippines
slnb
outcomes
sentinel
blue dye
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Yap RV
De La Serna FM
Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines
description Ralph Victor Yap, Frances Marion De La Serna Department of Surgery, Cebu Doctors’ University Hospital, Cebu City, Cebu, PhilippinesCorrespondence: Ralph Victor YapDepartment of Surgery, Cebu Doctors’ University Hospital, Osmeña Boulevard, Cebu City 6000, Cebu, PhilippinesTel +63 917 130 1923Fax +63 32 255 5555Email rvyapmd@gmail.comPurpose: This study aimed to share our experience with SLNB in the Filipino population with early breast cancer.Patients and Methods: A retrospective review was done on all patients with confirmed invasive breast carcinoma, tumor size of 5 cm or less (T1/T2), who preoperatively had no clinical signs of axillary metastasis and subsequently underwent SLNB with blue dye method from January 01, 2008 to December 31, 2017. Clinicopathologic profiles were recorded. Outcomes of patients who had SLNB only were assessed.Results: One hundred twenty-nine patients matched the inclusion criteria with a mean age of 54.3 years. The majority (88.4%) had a total mastectomy. Invasive ductal carcinoma (65.1%) was the most common tumor. Estrogen and progesterone receptors were positive in 69% and 61.2% respectively while only 28.7% were HER2 positive. SLNB was successfully carried out in 126 (97.7%) patients with a range of 2– 4 SLNs harvested. Thirty-four (26.4%) patients had completion ALND. With a median of 25 months follow-up, 75 out of 95 patients who underwent SLNB alone had follow-up data. Forty-six (61.3%) patients had seroma formation. One (1.3%) patient developed arm paresthesia, 2 (2.7%) local (chest wall) and 2 (2.7%) axillary recurrences after a negative SLNB. None of the patients developed lymphedema.Conclusion: The blue dye method alone is acceptable and can be readily employed in institutions with limited resources. Even with the limited population, the morbidity and oncologic outcomes of patients who underwent SLNB alone were low and comparable to similar international published data. SLNB should be the preferred method for staging the axilla.Keywords: breast cancer, Philippines, SLNB, outcomes, sentinel, blue dye
format article
author Yap RV
De La Serna FM
author_facet Yap RV
De La Serna FM
author_sort Yap RV
title Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines
title_short Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines
title_full Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines
title_fullStr Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines
title_full_unstemmed Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer – A Single-Institution Experience in the Philippines
title_sort outcomes of sentinel lymph node biopsy using blue dye method for early breast cancer – a single-institution experience in the philippines
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/2bf4cd8dbb524f0d9a39af9accb31210
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