Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulation and proliferation in breast cancer cells.

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Autores principales:	Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bf99c4671d44e71969d21873ef164c4
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spelling	oai:doaj.org-article:2bf99c4671d44e71969d21873ef164c42021-12-02T17:32:29ZTargeted NUDT5 inhibitors block hormone signaling in breast cancer cells10.1038/s41467-017-02293-72041-1723https://doaj.org/article/2bf99c4671d44e71969d21873ef164c42018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02293-7https://doaj.org/toc/2041-1723NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulation and proliferation in breast cancer cells.Brent D. G. PageNicholas C. K. ValerieRoni H. G. WrightOlov WallnerRebecka IsakssonMegan CarterSean G. RuddOlga LosevaAnn-Sofie JemthIngrid AlmlöfJofre Font-MateuSabin Llona-MinguezPawel BaranczewskiFredrik JeppssonEvert HomanHelena AlmqvistHanna AxelssonShruti RegmiAnna-Lena GustavssonThomas LundbäckMartin ScobieKia StrömbergPål StenmarkMiguel BeatoThomas HelledayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brent D. G. Page Nicholas C. K. Valerie Roni H. G. Wright Olov Wallner Rebecka Isaksson Megan Carter Sean G. Rudd Olga Loseva Ann-Sofie Jemth Ingrid Almlöf Jofre Font-Mateu Sabin Llona-Minguez Pawel Baranczewski Fredrik Jeppsson Evert Homan Helena Almqvist Hanna Axelsson Shruti Regmi Anna-Lena Gustavsson Thomas Lundbäck Martin Scobie Kia Strömberg Pål Stenmark Miguel Beato Thomas Helleday Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
description	NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulation and proliferation in breast cancer cells.
format	article
author	Brent D. G. Page Nicholas C. K. Valerie Roni H. G. Wright Olov Wallner Rebecka Isaksson Megan Carter Sean G. Rudd Olga Loseva Ann-Sofie Jemth Ingrid Almlöf Jofre Font-Mateu Sabin Llona-Minguez Pawel Baranczewski Fredrik Jeppsson Evert Homan Helena Almqvist Hanna Axelsson Shruti Regmi Anna-Lena Gustavsson Thomas Lundbäck Martin Scobie Kia Strömberg Pål Stenmark Miguel Beato Thomas Helleday
author_facet	Brent D. G. Page Nicholas C. K. Valerie Roni H. G. Wright Olov Wallner Rebecka Isaksson Megan Carter Sean G. Rudd Olga Loseva Ann-Sofie Jemth Ingrid Almlöf Jofre Font-Mateu Sabin Llona-Minguez Pawel Baranczewski Fredrik Jeppsson Evert Homan Helena Almqvist Hanna Axelsson Shruti Regmi Anna-Lena Gustavsson Thomas Lundbäck Martin Scobie Kia Strömberg Pål Stenmark Miguel Beato Thomas Helleday
author_sort	Brent D. G. Page
title	Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
title_short	Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
title_full	Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
title_fullStr	Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
title_full_unstemmed	Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
title_sort	targeted nudt5 inhibitors block hormone signaling in breast cancer cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2bf99c4671d44e71969d21873ef164c4
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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

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