Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women

Abstract Limited evidence revealed conflicting results on relationship between phthalate exposure and clinical pregnancy loss (gestational weeks >6). A prospective cohort study in Chinese pregnant women (n = 3220) was conducted to investigate the association between urinary phthalate metabolites...

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Autores principales:	Hui Gao, Yun-wei Zhang, Kun Huang, Shuang-qin Yan, Lei-jing Mao, Xing Ge, Ye-qing Xu, Yuan-yuan Xu, Jie Sheng, Zhong-xiu Jin, Peng Zhu, Xu-guang Tao, Jia-hu Hao, Fang-biao Tao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2bfed666b1ab4cc992bfa445c367c170
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spelling	oai:doaj.org-article:2bfed666b1ab4cc992bfa445c367c1702021-12-02T11:41:00ZUrinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women10.1038/s41598-017-06450-22045-2322https://doaj.org/article/2bfed666b1ab4cc992bfa445c367c1702017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06450-2https://doaj.org/toc/2045-2322Abstract Limited evidence revealed conflicting results on relationship between phthalate exposure and clinical pregnancy loss (gestational weeks >6). A prospective cohort study in Chinese pregnant women (n = 3220) was conducted to investigate the association between urinary phthalate metabolites and clinical pregnancy loss (gestational weeks 6 to 27; n = 109). Morning urine samples during gestational weeks 5 to 14 (mean 10.42) were collected to measure monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP). The concentrations of low- and high-molecular weight phthalate metabolites (ΣLMWP <250 Da and ΣHMWP >250 Da) were calculated. Adjusted logistic regression models showed increased risks of clinical pregnancy loss in women with higher creatinine- normalized concentrations of MEP, MBP, MEOHP, MEHHP, ΣLMWP and ΣHMWP. Stratified analysis by gestational weeks (10 weeks) of miscarriage indicated positive associations of MEP, MEOHP, MEHHP and ΣHMWP with embryonic loss (during gestational weeks 6 to 10). The only association of foetal loss (during gestational weeks 11 to 27) was observed with MEHHP. Our findings suggested that Chinese women who were exposed to phthalates during early pregnancy had an increased risk of clinical pregnancy loss, especially embryonic loss.Hui GaoYun-wei ZhangKun HuangShuang-qin YanLei-jing MaoXing GeYe-qing XuYuan-yuan XuJie ShengZhong-xiu JinPeng ZhuXu-guang TaoJia-hu HaoFang-biao TaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui Gao Yun-wei Zhang Kun Huang Shuang-qin Yan Lei-jing Mao Xing Ge Ye-qing Xu Yuan-yuan Xu Jie Sheng Zhong-xiu Jin Peng Zhu Xu-guang Tao Jia-hu Hao Fang-biao Tao Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women
description	Abstract Limited evidence revealed conflicting results on relationship between phthalate exposure and clinical pregnancy loss (gestational weeks >6). A prospective cohort study in Chinese pregnant women (n = 3220) was conducted to investigate the association between urinary phthalate metabolites and clinical pregnancy loss (gestational weeks 6 to 27; n = 109). Morning urine samples during gestational weeks 5 to 14 (mean 10.42) were collected to measure monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP). The concentrations of low- and high-molecular weight phthalate metabolites (ΣLMWP <250 Da and ΣHMWP >250 Da) were calculated. Adjusted logistic regression models showed increased risks of clinical pregnancy loss in women with higher creatinine- normalized concentrations of MEP, MBP, MEOHP, MEHHP, ΣLMWP and ΣHMWP. Stratified analysis by gestational weeks (10 weeks) of miscarriage indicated positive associations of MEP, MEOHP, MEHHP and ΣHMWP with embryonic loss (during gestational weeks 6 to 10). The only association of foetal loss (during gestational weeks 11 to 27) was observed with MEHHP. Our findings suggested that Chinese women who were exposed to phthalates during early pregnancy had an increased risk of clinical pregnancy loss, especially embryonic loss.
format	article
author	Hui Gao Yun-wei Zhang Kun Huang Shuang-qin Yan Lei-jing Mao Xing Ge Ye-qing Xu Yuan-yuan Xu Jie Sheng Zhong-xiu Jin Peng Zhu Xu-guang Tao Jia-hu Hao Fang-biao Tao
author_facet	Hui Gao Yun-wei Zhang Kun Huang Shuang-qin Yan Lei-jing Mao Xing Ge Ye-qing Xu Yuan-yuan Xu Jie Sheng Zhong-xiu Jin Peng Zhu Xu-guang Tao Jia-hu Hao Fang-biao Tao
author_sort	Hui Gao
title	Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women
title_short	Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women
title_full	Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women
title_fullStr	Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women
title_full_unstemmed	Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women
title_sort	urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in chinese women
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2bfed666b1ab4cc992bfa445c367c170
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Urinary concentrations of phthalate metabolites in early pregnancy associated with clinical pregnancy loss in Chinese women

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