Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.

<h4>Background</h4>Cardiac remodelling after AMI is characterized by molecular and cellular mechanisms involving both the ischemic and non-ischemic myocardium. The extent of right ventricular (RV) dilatation and dysfunction and its relation to pulmonary hypertension (PH) following AMI ar...

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Autores principales:	Stefano Toldo, Herman J Bogaard, Benjamin W Van Tassell, Eleonora Mezzaroma, Ignacio M Seropian, Roshanak Robati, Fadi N Salloum, Norbert F Voelkel, Antonio Abbate
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c00a16995ff4d00ad85adc855b2adaa
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spelling	oai:doaj.org-article:2c00a16995ff4d00ad85adc855b2adaa2021-11-18T06:56:52ZRight ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.1932-620310.1371/journal.pone.0018102https://doaj.org/article/2c00a16995ff4d00ad85adc855b2adaa2011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21455304/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cardiac remodelling after AMI is characterized by molecular and cellular mechanisms involving both the ischemic and non-ischemic myocardium. The extent of right ventricular (RV) dilatation and dysfunction and its relation to pulmonary hypertension (PH) following AMI are unknown. The aim of the current study was to evaluate changes in dimensions and function of the RV following acute myocardial infarction (AMI) involving the left ventricle (LV).<h4>Methods</h4>We assessed changes in RV dimensions and function 1 week following experimental AMI involving the LV free wall in 10 mice and assessed for LV and RV dimensions and function and for the presence and degree of PH.<h4>Results</h4>RV fractional area change and tricuspidal annular plane systolic excursion significantly declined by 33% (P = 0.021) and 28% (P = 0.001) respectively. Right ventricular systolic pressure measured invasively in the mouse was within the normal values and unchanged following AMI.<h4>Conclusion</h4>AMI involving the LV and sparing the RV induces a significant acute decline in RV systolic function in the absence of pulmonary hypertension in the mouse indicating that RV dysfunction developed independent of changes in RV afterload.Stefano ToldoHerman J BogaardBenjamin W Van TassellEleonora MezzaromaIgnacio M SeropianRoshanak RobatiFadi N SalloumNorbert F VoelkelAntonio AbbatePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e18102 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Toldo Herman J Bogaard Benjamin W Van Tassell Eleonora Mezzaroma Ignacio M Seropian Roshanak Robati Fadi N Salloum Norbert F Voelkel Antonio Abbate Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
description	<h4>Background</h4>Cardiac remodelling after AMI is characterized by molecular and cellular mechanisms involving both the ischemic and non-ischemic myocardium. The extent of right ventricular (RV) dilatation and dysfunction and its relation to pulmonary hypertension (PH) following AMI are unknown. The aim of the current study was to evaluate changes in dimensions and function of the RV following acute myocardial infarction (AMI) involving the left ventricle (LV).<h4>Methods</h4>We assessed changes in RV dimensions and function 1 week following experimental AMI involving the LV free wall in 10 mice and assessed for LV and RV dimensions and function and for the presence and degree of PH.<h4>Results</h4>RV fractional area change and tricuspidal annular plane systolic excursion significantly declined by 33% (P = 0.021) and 28% (P = 0.001) respectively. Right ventricular systolic pressure measured invasively in the mouse was within the normal values and unchanged following AMI.<h4>Conclusion</h4>AMI involving the LV and sparing the RV induces a significant acute decline in RV systolic function in the absence of pulmonary hypertension in the mouse indicating that RV dysfunction developed independent of changes in RV afterload.
format	article
author	Stefano Toldo Herman J Bogaard Benjamin W Van Tassell Eleonora Mezzaroma Ignacio M Seropian Roshanak Robati Fadi N Salloum Norbert F Voelkel Antonio Abbate
author_facet	Stefano Toldo Herman J Bogaard Benjamin W Van Tassell Eleonora Mezzaroma Ignacio M Seropian Roshanak Robati Fadi N Salloum Norbert F Voelkel Antonio Abbate
author_sort	Stefano Toldo
title	Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
title_short	Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
title_full	Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
title_fullStr	Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
title_full_unstemmed	Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
title_sort	right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/2c00a16995ff4d00ad85adc855b2adaa
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Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.

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