Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy

The Ep400 chromatin remodeler determines genomic distribution of variant histones. In the current study, the authors show that loss of Ep400 in Schwann cells leads to aberrant expression of developmental regulators, and a peripheral neuropathy phenotype.

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Autores principales:	Franziska Fröb, Elisabeth Sock, Ernst. R. Tamm, Anna-Lena Saur, Simone Hillgärtner, Trevor J. Williams, Toshihiro Fujii, Rikiro Fukunaga, Michael Wegner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c01dc5a25984a1dbe35317ab8b430f2
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spelling	oai:doaj.org-article:2c01dc5a25984a1dbe35317ab8b430f22021-12-02T16:58:28ZEp400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy10.1038/s41467-019-10287-w2041-1723https://doaj.org/article/2c01dc5a25984a1dbe35317ab8b430f22019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10287-whttps://doaj.org/toc/2041-1723The Ep400 chromatin remodeler determines genomic distribution of variant histones. In the current study, the authors show that loss of Ep400 in Schwann cells leads to aberrant expression of developmental regulators, and a peripheral neuropathy phenotype.Franziska FröbElisabeth SockErnst. R. TammAnna-Lena SaurSimone HillgärtnerTrevor J. WilliamsToshihiro FujiiRikiro FukunagaMichael WegnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Franziska Fröb Elisabeth Sock Ernst. R. Tamm Anna-Lena Saur Simone Hillgärtner Trevor J. Williams Toshihiro Fujii Rikiro Fukunaga Michael Wegner Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy
description	The Ep400 chromatin remodeler determines genomic distribution of variant histones. In the current study, the authors show that loss of Ep400 in Schwann cells leads to aberrant expression of developmental regulators, and a peripheral neuropathy phenotype.
format	article
author	Franziska Fröb Elisabeth Sock Ernst. R. Tamm Anna-Lena Saur Simone Hillgärtner Trevor J. Williams Toshihiro Fujii Rikiro Fukunaga Michael Wegner
author_facet	Franziska Fröb Elisabeth Sock Ernst. R. Tamm Anna-Lena Saur Simone Hillgärtner Trevor J. Williams Toshihiro Fujii Rikiro Fukunaga Michael Wegner
author_sort	Franziska Fröb
title	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy
title_short	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy
title_full	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy
title_fullStr	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy
title_full_unstemmed	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy
title_sort	ep400 deficiency in schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2c01dc5a25984a1dbe35317ab8b430f2
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Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy

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