Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation

The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activation threshold and effector functions, thereby hintin...

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Autores principales:	Ulrika Norin, Carola Rintisch, Liesu Meng, Florian Forster, Diana Ekman, Jonatan Tuncel, Katrin Klocke, Johan Bäcklund, Min Yang, Michael Y. Bonner, Gonzalo Fernandez Lahore, Jaime James, Klementy Shchetynsky, Maria Bergquist, Inger Gjertsson, Norbert Hubner, Liselotte Bäckdahl, Rikard Holmdahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c060b0a7c8b44caaf676f45fd6b218d
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spelling	oai:doaj.org-article:2c060b0a7c8b44caaf676f45fd6b218d2021-12-02T13:57:43ZEndophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation10.1038/s41467-020-20586-22041-1723https://doaj.org/article/2c060b0a7c8b44caaf676f45fd6b218d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20586-2https://doaj.org/toc/2041-1723The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activation threshold and effector functions, thereby hinting a potential target for RA therapy.Ulrika NorinCarola RintischLiesu MengFlorian ForsterDiana EkmanJonatan TuncelKatrin KlockeJohan BäcklundMin YangMichael Y. BonnerGonzalo Fernandez LahoreJaime JamesKlementy ShchetynskyMaria BergquistInger GjertssonNorbert HubnerLiselotte BäckdahlRikard HolmdahlNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ulrika Norin Carola Rintisch Liesu Meng Florian Forster Diana Ekman Jonatan Tuncel Katrin Klocke Johan Bäcklund Min Yang Michael Y. Bonner Gonzalo Fernandez Lahore Jaime James Klementy Shchetynsky Maria Bergquist Inger Gjertsson Norbert Hubner Liselotte Bäckdahl Rikard Holmdahl Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
description	The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activation threshold and effector functions, thereby hinting a potential target for RA therapy.
format	article
author	Ulrika Norin Carola Rintisch Liesu Meng Florian Forster Diana Ekman Jonatan Tuncel Katrin Klocke Johan Bäcklund Min Yang Michael Y. Bonner Gonzalo Fernandez Lahore Jaime James Klementy Shchetynsky Maria Bergquist Inger Gjertsson Norbert Hubner Liselotte Bäckdahl Rikard Holmdahl
author_facet	Ulrika Norin Carola Rintisch Liesu Meng Florian Forster Diana Ekman Jonatan Tuncel Katrin Klocke Johan Bäcklund Min Yang Michael Y. Bonner Gonzalo Fernandez Lahore Jaime James Klementy Shchetynsky Maria Bergquist Inger Gjertsson Norbert Hubner Liselotte Bäckdahl Rikard Holmdahl
author_sort	Ulrika Norin
title	Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
title_short	Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
title_full	Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
title_fullStr	Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
title_full_unstemmed	Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
title_sort	endophilin a2 deficiency protects rodents from autoimmune arthritis by modulating t cell activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2c060b0a7c8b44caaf676f45fd6b218d
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Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation

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