Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation

Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation

The autoimmune disorder, rheumatoid arthritis (RA), has been associated with multiple pathophysiological factors. Here the authors show that deficiency in endophilin A2 in rodents protects them from experimental arthritis by altering T cell activation threshold and effector functions, thereby hintin...

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Main Authors: Ulrika Norin, Carola Rintisch, Liesu Meng, Florian Forster, Diana Ekman, Jonatan Tuncel, Katrin Klocke, Johan Bäcklund, Min Yang, Michael Y. Bonner, Gonzalo Fernandez Lahore, Jaime James, Klementy Shchetynsky, Maria Bergquist, Inger Gjertsson, Norbert Hubner, Liselotte Bäckdahl, Rikard Holmdahl
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/2c060b0a7c8b44caaf676f45fd6b218d
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https://doaj.org/article/2c060b0a7c8b44caaf676f45fd6b218d

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