Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2c0a011d044046398f11e576a0b58fa9 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2c0a011d044046398f11e576a0b58fa9 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2c0a011d044046398f11e576a0b58fa92021-12-02T10:48:29ZMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques10.1038/s41467-020-20141-z2041-1723https://doaj.org/article/2c0a011d044046398f11e576a0b58fa92020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20141-zhttps://doaj.org/toc/2041-1723Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques.Jeroen BaardmanSanne G. S. VerberkSaskia van der VeldenMarion J. J. GijbelsCindy P. P. A. van RoomenJudith C. SluimerJelle Y. BroosGuillermo R. GriffithKoen H. M. PrangeMichel van WeeghelSoufyan LakbirDouwe MolenaarElisa MeinsterAnnette E. NeeleGijs KooijHelga E. de VriesEsther LutgensKathryn E. WellenMenno P. J. de WintherJan Van den BosscheNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jeroen Baardman Sanne G. S. Verberk Saskia van der Velden Marion J. J. Gijbels Cindy P. P. A. van Roomen Judith C. Sluimer Jelle Y. Broos Guillermo R. Griffith Koen H. M. Prange Michel van Weeghel Soufyan Lakbir Douwe Molenaar Elisa Meinster Annette E. Neele Gijs Kooij Helga E. de Vries Esther Lutgens Kathryn E. Wellen Menno P. J. de Winther Jan Van den Bossche Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| description |
Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques. |
| format |
article |
| author |
Jeroen Baardman Sanne G. S. Verberk Saskia van der Velden Marion J. J. Gijbels Cindy P. P. A. van Roomen Judith C. Sluimer Jelle Y. Broos Guillermo R. Griffith Koen H. M. Prange Michel van Weeghel Soufyan Lakbir Douwe Molenaar Elisa Meinster Annette E. Neele Gijs Kooij Helga E. de Vries Esther Lutgens Kathryn E. Wellen Menno P. J. de Winther Jan Van den Bossche |
| author_facet |
Jeroen Baardman Sanne G. S. Verberk Saskia van der Velden Marion J. J. Gijbels Cindy P. P. A. van Roomen Judith C. Sluimer Jelle Y. Broos Guillermo R. Griffith Koen H. M. Prange Michel van Weeghel Soufyan Lakbir Douwe Molenaar Elisa Meinster Annette E. Neele Gijs Kooij Helga E. de Vries Esther Lutgens Kathryn E. Wellen Menno P. J. de Winther Jan Van den Bossche |
| author_sort |
Jeroen Baardman |
| title |
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_short |
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_full |
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_fullStr |
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_full_unstemmed |
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques |
| title_sort |
macrophage atp citrate lyase deficiency stabilizes atherosclerotic plaques |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/2c0a011d044046398f11e576a0b58fa9 |
| work_keys_str_mv |
AT jeroenbaardman macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT sannegsverberk macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT saskiavandervelden macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT marionjjgijbels macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT cindyppavanroomen macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT judithcsluimer macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT jelleybroos macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT guillermorgriffith macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT koenhmprange macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT michelvanweeghel macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT soufyanlakbir macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT douwemolenaar macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT elisameinster macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT annetteeneele macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT gijskooij macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT helgaedevries macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT estherlutgens macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT kathrynewellen macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT mennopjdewinther macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques AT janvandenbossche macrophageatpcitratelyasedeficiencystabilizesatheroscleroticplaques |
| _version_ |
1718396638226022400 |