GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS

Development of atherosclerosis and its clinical manifestations, i.e. unstable angina, myocardial infarction, and ischemic stroke, is largely determined by a genetic inheritance, particularly inherited variation of the genes encoding Toll-like receptors (TLRs), a major effector of innate immune syste...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	I. I. Zhidkova, A. V. Ponasenko, M. V. Khutornaya, A. G. Kutikhin, O. L. Barbarash
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	atherosclerosis gene polymorphisms toll-like receptors allelic variants innate immune receptors inflammation immune response Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2c0a14e9f0644449987c80fc1e88a8e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c0a14e9f0644449987c80fc1e88a8e3
record_format	dspace
spelling	oai:doaj.org-article:2c0a14e9f0644449987c80fc1e88a8e32021-11-18T08:03:46ZGENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS1563-06252313-741X10.15789/1563-0625-2017-3-241-254https://doaj.org/article/2c0a14e9f0644449987c80fc1e88a8e32017-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1258https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDevelopment of atherosclerosis and its clinical manifestations, i.e. unstable angina, myocardial infarction, and ischemic stroke, is largely determined by a genetic inheritance, particularly inherited variation of the genes encoding Toll-like receptors (TLRs), a major effector of innate immune system. Polymorphisms of the TLR genes may affect vascular inflammation, as well as plaque formation and its stability. Miriades of immune cells and bioactive substances are involved into pathogenesis of atherosclerosis. They exert different effects upon vascular wall and participate in development of universal inflammatory response. Local inflammatory reaction underlyes atherosclerotic plaque destabilization and endothelial dysfunction. This response is associated with TLR activation and induced synthesis of proinflammatory cytokines. Here we review the literature on the role of inherited variations within the TLR genes in the development and progression of atherosclerosis and its complications. Moreoxer, we conclude that a search for genomic markers of atherosclerosis, e.g., TLR gene polymorphisms, may be applied in personalized cardiovascular medicine, in order to predict clinical course and evolution of the disorder, like as to perform prophylactic measures aimed for prevention of the disease progression.I. I. ZhidkovaA. V. PonasenkoM. V. KhutornayaA. G. KutikhinO. L. BarbarashSPb RAACIarticleatherosclerosisgene polymorphismstoll-like receptorsallelic variantsinnate immune receptorsinflammationimmune responseImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 3, Pp 241-254 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	atherosclerosis gene polymorphisms toll-like receptors allelic variants innate immune receptors inflammation immune response Immunologic diseases. Allergy RC581-607
spellingShingle	atherosclerosis gene polymorphisms toll-like receptors allelic variants innate immune receptors inflammation immune response Immunologic diseases. Allergy RC581-607 I. I. Zhidkova A. V. Ponasenko M. V. Khutornaya A. G. Kutikhin O. L. Barbarash GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS
description	Development of atherosclerosis and its clinical manifestations, i.e. unstable angina, myocardial infarction, and ischemic stroke, is largely determined by a genetic inheritance, particularly inherited variation of the genes encoding Toll-like receptors (TLRs), a major effector of innate immune system. Polymorphisms of the TLR genes may affect vascular inflammation, as well as plaque formation and its stability. Miriades of immune cells and bioactive substances are involved into pathogenesis of atherosclerosis. They exert different effects upon vascular wall and participate in development of universal inflammatory response. Local inflammatory reaction underlyes atherosclerotic plaque destabilization and endothelial dysfunction. This response is associated with TLR activation and induced synthesis of proinflammatory cytokines. Here we review the literature on the role of inherited variations within the TLR genes in the development and progression of atherosclerosis and its complications. Moreoxer, we conclude that a search for genomic markers of atherosclerosis, e.g., TLR gene polymorphisms, may be applied in personalized cardiovascular medicine, in order to predict clinical course and evolution of the disorder, like as to perform prophylactic measures aimed for prevention of the disease progression.
format	article
author	I. I. Zhidkova A. V. Ponasenko M. V. Khutornaya A. G. Kutikhin O. L. Barbarash
author_facet	I. I. Zhidkova A. V. Ponasenko M. V. Khutornaya A. G. Kutikhin O. L. Barbarash
author_sort	I. I. Zhidkova
title	GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS
title_short	GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS
title_full	GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS
title_fullStr	GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS
title_full_unstemmed	GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS
title_sort	genomic factors (toll-like receptors genes) in development of atherosclerosis and its clinical manifestations
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/2c0a14e9f0644449987c80fc1e88a8e3
work_keys_str_mv	AT iizhidkova genomicfactorstolllikereceptorsgenesindevelopmentofatherosclerosisanditsclinicalmanifestations AT avponasenko genomicfactorstolllikereceptorsgenesindevelopmentofatherosclerosisanditsclinicalmanifestations AT mvkhutornaya genomicfactorstolllikereceptorsgenesindevelopmentofatherosclerosisanditsclinicalmanifestations AT agkutikhin genomicfactorstolllikereceptorsgenesindevelopmentofatherosclerosisanditsclinicalmanifestations AT olbarbarash genomicfactorstolllikereceptorsgenesindevelopmentofatherosclerosisanditsclinicalmanifestations
_version_	1718422406168576000

GENOMIC FACTORS (TOLL-LIKE RECEPTORS GENES) IN DEVELOPMENT OF ATHEROSCLEROSIS AND ITS CLINICAL MANIFESTATIONS

Ejemplares similares