Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.

<h4>Background/aims</h4>Hepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B virus (HBV) dual infection....

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Autores principales:	Hung-Yin Liu, Yi-Hung Lin, Pei-Ju Lin, Pei-Chien Tsai, Shu-Fen Liu, Ying-Chou Huang, Jia-Jiun Tsai, Ching-I Huang, Ming-Lun Yeh, Po-Cheng Liang, Zu-Yau Lin, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Chung-Feng Huang, Ming-Lung Yu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c0a72e49af04769bdd1121140c062bf
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spelling	oai:doaj.org-article:2c0a72e49af04769bdd1121140c062bf2021-12-02T20:09:43ZAnti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.1932-620310.1371/journal.pone.0254028https://doaj.org/article/2c0a72e49af04769bdd1121140c062bf2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254028https://doaj.org/toc/1932-6203<h4>Background/aims</h4>Hepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B virus (HBV) dual infection.<h4>Methods</h4>Anti-HCV seropositive patients who were treatment-naïve consecutively enrolled. Anti-HCV antibodies were detected using a commercially chemiluminescent microparticle immunoassay. HCV RNA was detected by real-time PCR method.<h4>Results</h4>A total of 1321 including1196 mono-infected and 125 HBV dually infected patients were analyzed. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001). Of the entire cohort, the anti-HCV cut-off value of 10 provided the best accuracy, 96.8%, with the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96.3%, 98.9%, 99.7% and 87.3% respectively. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001) and 9.36 (AUROC 1.00, P<0.0001) in patients with HCV mono-infection and HBV dual-infection respectively. Among the HBV dually infected patients, the accuracy of anti-HCV titer in predicting HCV viremia reached up to 100% with the cut-off value of 9. All the patients were HCV-viremic if their anti-HCV titer was greater than 9 (PPV 100%). On the other hand, all the patients were HCV non-viremic if their anti-HCV titer was less than 9 (NPV 100%).<h4>Conclusions</h4>Anti-HCV titer strongly predicted HCV viremia. This excellent performance could be generalized to either HCV mono-infected or HBV dually infected patients.Hung-Yin LiuYi-Hung LinPei-Ju LinPei-Chien TsaiShu-Fen LiuYing-Chou HuangJia-Jiun TsaiChing-I HuangMing-Lun YehPo-Cheng LiangZu-Yau LinChia-Yen DaiJee-Fu HuangWan-Long ChuangChung-Feng HuangMing-Lung YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254028 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hung-Yin Liu Yi-Hung Lin Pei-Ju Lin Pei-Chien Tsai Shu-Fen Liu Ying-Chou Huang Jia-Jiun Tsai Ching-I Huang Ming-Lun Yeh Po-Cheng Liang Zu-Yau Lin Chia-Yen Dai Jee-Fu Huang Wan-Long Chuang Chung-Feng Huang Ming-Lung Yu Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
description	<h4>Background/aims</h4>Hepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B virus (HBV) dual infection.<h4>Methods</h4>Anti-HCV seropositive patients who were treatment-naïve consecutively enrolled. Anti-HCV antibodies were detected using a commercially chemiluminescent microparticle immunoassay. HCV RNA was detected by real-time PCR method.<h4>Results</h4>A total of 1321 including1196 mono-infected and 125 HBV dually infected patients were analyzed. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001). Of the entire cohort, the anti-HCV cut-off value of 10 provided the best accuracy, 96.8%, with the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96.3%, 98.9%, 99.7% and 87.3% respectively. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, P<0.0001) and 9.36 (AUROC 1.00, P<0.0001) in patients with HCV mono-infection and HBV dual-infection respectively. Among the HBV dually infected patients, the accuracy of anti-HCV titer in predicting HCV viremia reached up to 100% with the cut-off value of 9. All the patients were HCV-viremic if their anti-HCV titer was greater than 9 (PPV 100%). On the other hand, all the patients were HCV non-viremic if their anti-HCV titer was less than 9 (NPV 100%).<h4>Conclusions</h4>Anti-HCV titer strongly predicted HCV viremia. This excellent performance could be generalized to either HCV mono-infected or HBV dually infected patients.
format	article
author	Hung-Yin Liu Yi-Hung Lin Pei-Ju Lin Pei-Chien Tsai Shu-Fen Liu Ying-Chou Huang Jia-Jiun Tsai Ching-I Huang Ming-Lun Yeh Po-Cheng Liang Zu-Yau Lin Chia-Yen Dai Jee-Fu Huang Wan-Long Chuang Chung-Feng Huang Ming-Lung Yu
author_facet	Hung-Yin Liu Yi-Hung Lin Pei-Ju Lin Pei-Chien Tsai Shu-Fen Liu Ying-Chou Huang Jia-Jiun Tsai Ching-I Huang Ming-Lun Yeh Po-Cheng Liang Zu-Yau Lin Chia-Yen Dai Jee-Fu Huang Wan-Long Chuang Chung-Feng Huang Ming-Lung Yu
author_sort	Hung-Yin Liu
title	Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
title_short	Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
title_full	Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
title_fullStr	Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
title_full_unstemmed	Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
title_sort	anti-hcv antibody titer highly predicts hcv viremia in patients with hepatitis b virus dual-infection.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2c0a72e49af04769bdd1121140c062bf
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Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.

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