On-target restoration of a split T cell-engaging antibody for precision immunotherapy
The restriction of appropriate tumour-specific antigens is a current limitation for T cell-engaging immunotherapy. Here, the authors have designed a new system constituted by two halve antibodies, which engage T cells once binding to two different antigens, to specifically eliminate double positive...
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Nature Portfolio
2019
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oai:doaj.org-article:2c0baf0c95d243a58f06fcb336d652c22021-12-02T16:57:44ZOn-target restoration of a split T cell-engaging antibody for precision immunotherapy10.1038/s41467-019-13196-02041-1723https://doaj.org/article/2c0baf0c95d243a58f06fcb336d652c22019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13196-0https://doaj.org/toc/2041-1723The restriction of appropriate tumour-specific antigens is a current limitation for T cell-engaging immunotherapy. Here, the authors have designed a new system constituted by two halve antibodies, which engage T cells once binding to two different antigens, to specifically eliminate double positive cells in preclinical leukemia and breast cancer mouse models.Agnes BanaszekThomas G. P. BummBoris NowotnyMaria GeisKim JacobMatthias WölflJohannes TrebingKirstin KuckaDina KouhestaniTea GogishviliBastian KrenzJustina LutzLeo RascheDirk HönemannHannes NeuweilerJulia C. HeibyRalf C. BargouHarald WajantHermann EinseleGert RiethmüllerGernot StuhlerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Agnes Banaszek Thomas G. P. Bumm Boris Nowotny Maria Geis Kim Jacob Matthias Wölfl Johannes Trebing Kirstin Kucka Dina Kouhestani Tea Gogishvili Bastian Krenz Justina Lutz Leo Rasche Dirk Hönemann Hannes Neuweiler Julia C. Heiby Ralf C. Bargou Harald Wajant Hermann Einsele Gert Riethmüller Gernot Stuhler On-target restoration of a split T cell-engaging antibody for precision immunotherapy |
| description |
The restriction of appropriate tumour-specific antigens is a current limitation for T cell-engaging immunotherapy. Here, the authors have designed a new system constituted by two halve antibodies, which engage T cells once binding to two different antigens, to specifically eliminate double positive cells in preclinical leukemia and breast cancer mouse models. |
| format |
article |
| author |
Agnes Banaszek Thomas G. P. Bumm Boris Nowotny Maria Geis Kim Jacob Matthias Wölfl Johannes Trebing Kirstin Kucka Dina Kouhestani Tea Gogishvili Bastian Krenz Justina Lutz Leo Rasche Dirk Hönemann Hannes Neuweiler Julia C. Heiby Ralf C. Bargou Harald Wajant Hermann Einsele Gert Riethmüller Gernot Stuhler |
| author_facet |
Agnes Banaszek Thomas G. P. Bumm Boris Nowotny Maria Geis Kim Jacob Matthias Wölfl Johannes Trebing Kirstin Kucka Dina Kouhestani Tea Gogishvili Bastian Krenz Justina Lutz Leo Rasche Dirk Hönemann Hannes Neuweiler Julia C. Heiby Ralf C. Bargou Harald Wajant Hermann Einsele Gert Riethmüller Gernot Stuhler |
| author_sort |
Agnes Banaszek |
| title |
On-target restoration of a split T cell-engaging antibody for precision immunotherapy |
| title_short |
On-target restoration of a split T cell-engaging antibody for precision immunotherapy |
| title_full |
On-target restoration of a split T cell-engaging antibody for precision immunotherapy |
| title_fullStr |
On-target restoration of a split T cell-engaging antibody for precision immunotherapy |
| title_full_unstemmed |
On-target restoration of a split T cell-engaging antibody for precision immunotherapy |
| title_sort |
on-target restoration of a split t cell-engaging antibody for precision immunotherapy |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2c0baf0c95d243a58f06fcb336d652c2 |
| work_keys_str_mv |
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