Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer´s disease. Here authors present the 3D- structure of an Aβ oligomer formed in a membrane mimicking environment and observe that Aβ tetramers and octamers inserted into lip...

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Autores principales:	Sonia Ciudad, Eduard Puig, Thomas Botzanowski, Moeen Meigooni, Andres S. Arango, Jimmy Do, Maxim Mayzel, Mariam Bayoumi, Stéphane Chaignepain, Giovanni Maglia, Sarah Cianferani, Vladislav Orekhov, Emad Tajkhorshid, Benjamin Bardiaux, Natàlia Carulla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c0e9ea1270e440fb213d992e9ac74ae
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spelling	oai:doaj.org-article:2c0e9ea1270e440fb213d992e9ac74ae2021-12-02T17:39:52ZAβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage10.1038/s41467-020-16566-12041-1723https://doaj.org/article/2c0e9ea1270e440fb213d992e9ac74ae2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16566-1https://doaj.org/toc/2041-1723Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer´s disease. Here authors present the 3D- structure of an Aβ oligomer formed in a membrane mimicking environment and observe that Aβ tetramers and octamers inserted into lipid bilayers as well-defined pores.Sonia CiudadEduard PuigThomas BotzanowskiMoeen MeigooniAndres S. ArangoJimmy DoMaxim MayzelMariam BayoumiStéphane ChaignepainGiovanni MagliaSarah CianferaniVladislav OrekhovEmad TajkhorshidBenjamin BardiauxNatàlia CarullaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sonia Ciudad Eduard Puig Thomas Botzanowski Moeen Meigooni Andres S. Arango Jimmy Do Maxim Mayzel Mariam Bayoumi Stéphane Chaignepain Giovanni Maglia Sarah Cianferani Vladislav Orekhov Emad Tajkhorshid Benjamin Bardiaux Natàlia Carulla Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
description	Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer´s disease. Here authors present the 3D- structure of an Aβ oligomer formed in a membrane mimicking environment and observe that Aβ tetramers and octamers inserted into lipid bilayers as well-defined pores.
format	article
author	Sonia Ciudad Eduard Puig Thomas Botzanowski Moeen Meigooni Andres S. Arango Jimmy Do Maxim Mayzel Mariam Bayoumi Stéphane Chaignepain Giovanni Maglia Sarah Cianferani Vladislav Orekhov Emad Tajkhorshid Benjamin Bardiaux Natàlia Carulla
author_facet	Sonia Ciudad Eduard Puig Thomas Botzanowski Moeen Meigooni Andres S. Arango Jimmy Do Maxim Mayzel Mariam Bayoumi Stéphane Chaignepain Giovanni Maglia Sarah Cianferani Vladislav Orekhov Emad Tajkhorshid Benjamin Bardiaux Natàlia Carulla
author_sort	Sonia Ciudad
title	Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
title_short	Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
title_full	Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
title_fullStr	Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
title_full_unstemmed	Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
title_sort	aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2c0e9ea1270e440fb213d992e9ac74ae
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Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

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