BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1

The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors.

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Autores principales:	Sen Zhu, Dongyu Zhao, Lin Yan, Weihua Jiang, Jung-Sun Kim, Bingnan Gu, Qipeng Liu, Rui Wang, Bo Xia, Jonathan C. Zhao, Gang Song, Wenyi Mi, Rong-Fu Wang, Xiaobing Shi, Hung-Ming Lam, Xuesen Dong, Jindan Yu, Kaifu Chen, Qi Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c11102c772b403f8c968a42953aed26
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spelling	oai:doaj.org-article:2c11102c772b403f8c968a42953aed262021-12-02T17:31:16ZBMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 110.1038/s41467-018-02863-32041-1723https://doaj.org/article/2c11102c772b403f8c968a42953aed262018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02863-3https://doaj.org/toc/2041-1723The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors.Sen ZhuDongyu ZhaoLin YanWeihua JiangJung-Sun KimBingnan GuQipeng LiuRui WangBo XiaJonathan C. ZhaoGang SongWenyi MiRong-Fu WangXiaobing ShiHung-Ming LamXuesen DongJindan YuKaifu ChenQi CaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sen Zhu Dongyu Zhao Lin Yan Weihua Jiang Jung-Sun Kim Bingnan Gu Qipeng Liu Rui Wang Bo Xia Jonathan C. Zhao Gang Song Wenyi Mi Rong-Fu Wang Xiaobing Shi Hung-Ming Lam Xuesen Dong Jindan Yu Kaifu Chen Qi Cao BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
description	The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors.
format	article
author	Sen Zhu Dongyu Zhao Lin Yan Weihua Jiang Jung-Sun Kim Bingnan Gu Qipeng Liu Rui Wang Bo Xia Jonathan C. Zhao Gang Song Wenyi Mi Rong-Fu Wang Xiaobing Shi Hung-Ming Lam Xuesen Dong Jindan Yu Kaifu Chen Qi Cao
author_facet	Sen Zhu Dongyu Zhao Lin Yan Weihua Jiang Jung-Sun Kim Bingnan Gu Qipeng Liu Rui Wang Bo Xia Jonathan C. Zhao Gang Song Wenyi Mi Rong-Fu Wang Xiaobing Shi Hung-Ming Lam Xuesen Dong Jindan Yu Kaifu Chen Qi Cao
author_sort	Sen Zhu
title	BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
title_short	BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
title_full	BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
title_fullStr	BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
title_full_unstemmed	BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
title_sort	bmi1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2c11102c772b403f8c968a42953aed26
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BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1

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