Aqueous humor dynamics in human eye: A lattice Boltzmann study

This paper presents a lattice Boltzmann model to simulate the aqueous humor (AH) dynamics in the human eye by involving incompressible Navier-Stokes flow, heat convection and diffusion, and Darcy seepage flow. Verifying simulations indicate that the model is stable, convergent and robust. Further in...

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Autores principales: Zhangrong Qin, Lingjuan Meng, Fan Yang, Chaoying Zhang, Binghai Wen
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Lenguaje:EN
Publicado: AIMS Press 2021
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Acceso en línea:https://doaj.org/article/2c13e3e136394834b982382b5eaf604f
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spelling oai:doaj.org-article:2c13e3e136394834b982382b5eaf604f2021-11-08T03:04:57ZAqueous humor dynamics in human eye: A lattice Boltzmann study10.3934/mbe.20212551551-0018https://doaj.org/article/2c13e3e136394834b982382b5eaf604f2021-06-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021255?viewType=HTMLhttps://doaj.org/toc/1551-0018This paper presents a lattice Boltzmann model to simulate the aqueous humor (AH) dynamics in the human eye by involving incompressible Navier-Stokes flow, heat convection and diffusion, and Darcy seepage flow. Verifying simulations indicate that the model is stable, convergent and robust. Further investigations were carried out, including the effects of heat convection and buoyancy, AH production rate, permeability of trabecular meshwork, viscosity of AH and anterior chamber angle on intraocular pressure (IOP). The heat convection and diffusion can significantly affect the flow patterns in the healthy eye, and the IOP can be controlled by increasing the anterior chamber angle or decreasing the secretion rate, the drainage resistance and viscosity of AH. However, the IOP is insensitive to the viscosity of AH, which may be one of the causes that the viscosity would not have been considered as a factor for controlling the IOP. It's interesting that all these factors have more significant influences on the IOP in pathologic eye than healthy one. The temperature difference and the eye-orientation have obvious influence on the cornea and iris wall shear stresses. The present model and simulation results are expected to provide an alternative tool and theoretical reference for the study of AH dynamics.Zhangrong QinLingjuan MengFan YangChaoying ZhangBinghai WenAIMS Pressarticlelattice boltzmann methodaqueous humor dynamicsincompressible navier-stokes equationconvection diffusion equationdarcy equationboussinesq approximationBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 5, Pp 5006-5028 (2021)
institution DOAJ
collection DOAJ
language EN
topic lattice boltzmann method
aqueous humor dynamics
incompressible navier-stokes equation
convection diffusion equation
darcy equation
boussinesq approximation
Biotechnology
TP248.13-248.65
Mathematics
QA1-939
spellingShingle lattice boltzmann method
aqueous humor dynamics
incompressible navier-stokes equation
convection diffusion equation
darcy equation
boussinesq approximation
Biotechnology
TP248.13-248.65
Mathematics
QA1-939
Zhangrong Qin
Lingjuan Meng
Fan Yang
Chaoying Zhang
Binghai Wen
Aqueous humor dynamics in human eye: A lattice Boltzmann study
description This paper presents a lattice Boltzmann model to simulate the aqueous humor (AH) dynamics in the human eye by involving incompressible Navier-Stokes flow, heat convection and diffusion, and Darcy seepage flow. Verifying simulations indicate that the model is stable, convergent and robust. Further investigations were carried out, including the effects of heat convection and buoyancy, AH production rate, permeability of trabecular meshwork, viscosity of AH and anterior chamber angle on intraocular pressure (IOP). The heat convection and diffusion can significantly affect the flow patterns in the healthy eye, and the IOP can be controlled by increasing the anterior chamber angle or decreasing the secretion rate, the drainage resistance and viscosity of AH. However, the IOP is insensitive to the viscosity of AH, which may be one of the causes that the viscosity would not have been considered as a factor for controlling the IOP. It's interesting that all these factors have more significant influences on the IOP in pathologic eye than healthy one. The temperature difference and the eye-orientation have obvious influence on the cornea and iris wall shear stresses. The present model and simulation results are expected to provide an alternative tool and theoretical reference for the study of AH dynamics.
format article
author Zhangrong Qin
Lingjuan Meng
Fan Yang
Chaoying Zhang
Binghai Wen
author_facet Zhangrong Qin
Lingjuan Meng
Fan Yang
Chaoying Zhang
Binghai Wen
author_sort Zhangrong Qin
title Aqueous humor dynamics in human eye: A lattice Boltzmann study
title_short Aqueous humor dynamics in human eye: A lattice Boltzmann study
title_full Aqueous humor dynamics in human eye: A lattice Boltzmann study
title_fullStr Aqueous humor dynamics in human eye: A lattice Boltzmann study
title_full_unstemmed Aqueous humor dynamics in human eye: A lattice Boltzmann study
title_sort aqueous humor dynamics in human eye: a lattice boltzmann study
publisher AIMS Press
publishDate 2021
url https://doaj.org/article/2c13e3e136394834b982382b5eaf604f
work_keys_str_mv AT zhangrongqin aqueoushumordynamicsinhumaneyealatticeboltzmannstudy
AT lingjuanmeng aqueoushumordynamicsinhumaneyealatticeboltzmannstudy
AT fanyang aqueoushumordynamicsinhumaneyealatticeboltzmannstudy
AT chaoyingzhang aqueoushumordynamicsinhumaneyealatticeboltzmannstudy
AT binghaiwen aqueoushumordynamicsinhumaneyealatticeboltzmannstudy
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