Phospholipid translocation captured in a bifunctional membrane protein MprF
The Multiple Peptide Resistance Factors (MprFs) utilize two separate domains to synthesize and translocate aminoacyl phospholipids to the outer leaflets of bacterial membranes. Here authors present cryo-electron microscopy structures of MprF homodimer from Rhizobium tropici (RtMprF) at two different...
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2021
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oai:doaj.org-article:2c1794c5fd6448e9afb654626ed56d7e2021-12-02T16:51:30ZPhospholipid translocation captured in a bifunctional membrane protein MprF10.1038/s41467-021-23248-z2041-1723https://doaj.org/article/2c1794c5fd6448e9afb654626ed56d7e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23248-zhttps://doaj.org/toc/2041-1723The Multiple Peptide Resistance Factors (MprFs) utilize two separate domains to synthesize and translocate aminoacyl phospholipids to the outer leaflets of bacterial membranes. Here authors present cryo-electron microscopy structures of MprF homodimer from Rhizobium tropici (RtMprF) at two different states in complex with lysyl-phosphatidylglycerol (LysPG).Danfeng SongHaizhan JiaoZhenfeng LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Danfeng Song Haizhan Jiao Zhenfeng Liu Phospholipid translocation captured in a bifunctional membrane protein MprF |
description |
The Multiple Peptide Resistance Factors (MprFs) utilize two separate domains to synthesize and translocate aminoacyl phospholipids to the outer leaflets of bacterial membranes. Here authors present cryo-electron microscopy structures of MprF homodimer from Rhizobium tropici (RtMprF) at two different states in complex with lysyl-phosphatidylglycerol (LysPG). |
format |
article |
author |
Danfeng Song Haizhan Jiao Zhenfeng Liu |
author_facet |
Danfeng Song Haizhan Jiao Zhenfeng Liu |
author_sort |
Danfeng Song |
title |
Phospholipid translocation captured in a bifunctional membrane protein MprF |
title_short |
Phospholipid translocation captured in a bifunctional membrane protein MprF |
title_full |
Phospholipid translocation captured in a bifunctional membrane protein MprF |
title_fullStr |
Phospholipid translocation captured in a bifunctional membrane protein MprF |
title_full_unstemmed |
Phospholipid translocation captured in a bifunctional membrane protein MprF |
title_sort |
phospholipid translocation captured in a bifunctional membrane protein mprf |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/2c1794c5fd6448e9afb654626ed56d7e |
work_keys_str_mv |
AT danfengsong phospholipidtranslocationcapturedinabifunctionalmembraneproteinmprf AT haizhanjiao phospholipidtranslocationcapturedinabifunctionalmembraneproteinmprf AT zhenfengliu phospholipidtranslocationcapturedinabifunctionalmembraneproteinmprf |
_version_ |
1718382908494839808 |