Phospholipid translocation captured in a bifunctional membrane protein MprF

The Multiple Peptide Resistance Factors (MprFs) utilize two separate domains to synthesize and translocate aminoacyl phospholipids to the outer leaflets of bacterial membranes. Here authors present cryo-electron microscopy structures of MprF homodimer from Rhizobium tropici (RtMprF) at two different...

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Autores principales: Danfeng Song, Haizhan Jiao, Zhenfeng Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2c1794c5fd6448e9afb654626ed56d7e
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spelling oai:doaj.org-article:2c1794c5fd6448e9afb654626ed56d7e2021-12-02T16:51:30ZPhospholipid translocation captured in a bifunctional membrane protein MprF10.1038/s41467-021-23248-z2041-1723https://doaj.org/article/2c1794c5fd6448e9afb654626ed56d7e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23248-zhttps://doaj.org/toc/2041-1723The Multiple Peptide Resistance Factors (MprFs) utilize two separate domains to synthesize and translocate aminoacyl phospholipids to the outer leaflets of bacterial membranes. Here authors present cryo-electron microscopy structures of MprF homodimer from Rhizobium tropici (RtMprF) at two different states in complex with lysyl-phosphatidylglycerol (LysPG).Danfeng SongHaizhan JiaoZhenfeng LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Danfeng Song
Haizhan Jiao
Zhenfeng Liu
Phospholipid translocation captured in a bifunctional membrane protein MprF
description The Multiple Peptide Resistance Factors (MprFs) utilize two separate domains to synthesize and translocate aminoacyl phospholipids to the outer leaflets of bacterial membranes. Here authors present cryo-electron microscopy structures of MprF homodimer from Rhizobium tropici (RtMprF) at two different states in complex with lysyl-phosphatidylglycerol (LysPG).
format article
author Danfeng Song
Haizhan Jiao
Zhenfeng Liu
author_facet Danfeng Song
Haizhan Jiao
Zhenfeng Liu
author_sort Danfeng Song
title Phospholipid translocation captured in a bifunctional membrane protein MprF
title_short Phospholipid translocation captured in a bifunctional membrane protein MprF
title_full Phospholipid translocation captured in a bifunctional membrane protein MprF
title_fullStr Phospholipid translocation captured in a bifunctional membrane protein MprF
title_full_unstemmed Phospholipid translocation captured in a bifunctional membrane protein MprF
title_sort phospholipid translocation captured in a bifunctional membrane protein mprf
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2c1794c5fd6448e9afb654626ed56d7e
work_keys_str_mv AT danfengsong phospholipidtranslocationcapturedinabifunctionalmembraneproteinmprf
AT haizhanjiao phospholipidtranslocationcapturedinabifunctionalmembraneproteinmprf
AT zhenfengliu phospholipidtranslocationcapturedinabifunctionalmembraneproteinmprf
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