Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release

The effects of norepinephrine on sensory processing in cortical networks are altered by recreational drugs like ethanol. The authors show that ethanol suppresses the activation of astrocytes by inhibiting norepinephrine release which may contribute to the cognitive effects of alcohol intoxication.

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Autores principales: Liang Ye, Murat Orynbayev, Xiangyu Zhu, Eunice Y. Lim, Ram R. Dereddi, Amit Agarwal, Dwight E. Bergles, Manzoor A. Bhat, Martin Paukert
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2c1ad302fc1a4bc19e4ebac3ad4638f3
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spelling oai:doaj.org-article:2c1ad302fc1a4bc19e4ebac3ad4638f32021-12-02T15:39:24ZEthanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release10.1038/s41467-020-19475-52041-1723https://doaj.org/article/2c1ad302fc1a4bc19e4ebac3ad4638f32020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19475-5https://doaj.org/toc/2041-1723The effects of norepinephrine on sensory processing in cortical networks are altered by recreational drugs like ethanol. The authors show that ethanol suppresses the activation of astrocytes by inhibiting norepinephrine release which may contribute to the cognitive effects of alcohol intoxication.Liang YeMurat OrynbayevXiangyu ZhuEunice Y. LimRam R. DereddiAmit AgarwalDwight E. BerglesManzoor A. BhatMartin PaukertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Liang Ye
Murat Orynbayev
Xiangyu Zhu
Eunice Y. Lim
Ram R. Dereddi
Amit Agarwal
Dwight E. Bergles
Manzoor A. Bhat
Martin Paukert
Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
description The effects of norepinephrine on sensory processing in cortical networks are altered by recreational drugs like ethanol. The authors show that ethanol suppresses the activation of astrocytes by inhibiting norepinephrine release which may contribute to the cognitive effects of alcohol intoxication.
format article
author Liang Ye
Murat Orynbayev
Xiangyu Zhu
Eunice Y. Lim
Ram R. Dereddi
Amit Agarwal
Dwight E. Bergles
Manzoor A. Bhat
Martin Paukert
author_facet Liang Ye
Murat Orynbayev
Xiangyu Zhu
Eunice Y. Lim
Ram R. Dereddi
Amit Agarwal
Dwight E. Bergles
Manzoor A. Bhat
Martin Paukert
author_sort Liang Ye
title Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
title_short Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
title_full Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
title_fullStr Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
title_full_unstemmed Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
title_sort ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2c1ad302fc1a4bc19e4ebac3ad4638f3
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AT muratorynbayev ethanolabolishesvigilancedependentastroglianetworkactivationinmicebyinhibitingnorepinephrinerelease
AT xiangyuzhu ethanolabolishesvigilancedependentastroglianetworkactivationinmicebyinhibitingnorepinephrinerelease
AT euniceylim ethanolabolishesvigilancedependentastroglianetworkactivationinmicebyinhibitingnorepinephrinerelease
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