Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery

Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery

Abstract Human carbonic anhydrase XII (hCA XII) isozyme is of high therapeutic value as a pharmacological target and biomarker for different types of cancer. The hCA XII is one of the crucial effectors that regulates extracellular and intracellular pH and affects cancer cell proliferation, invasion,...

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Main Authors: Mohammad M. Al-Sanea, Garri Chilingaryan, Narek Abelyan, Grigor Arakelov, Harutyun Sahakyan, Vahram G. Arakelov, Karen Nazaryan, Shaimaa Hussein, Gharam M. Alazmi, Haifa E. Alsharari, Waad M. Al-faraj, Faten S. Alruwaili, Nouf Q. Albilasi, Tahani S. Alsharari, Abdulaziz A. S. Alsaleh, Turki M. Alazmi, Atiah H. Almalki, Nasser H. Alotaibi, Mohamed A. Abdelgawad
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/2c1d4ac6a4d343049a08b2c705fe9f50
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