Tissue alkalosis in cold-ischemia time

Tissue alkalosis in cold-ischemia time

Abstract The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-or...

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Autores principales: V. Denninghoff, E. H. R. Olivieri, C. Fresno, A. Uceda, L. Mota, A. P. Suenaga, D. M. Carraro, V. R. Martins, A. Avagnina, F. A. Soares, A. H. J. Fróes Marques Campos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
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R
Science
Q
Acceso en línea:https://doaj.org/article/2c20798e849a4c2e999d60c1a07ee088
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spelling oai:doaj.org-article:2c20798e849a4c2e999d60c1a07ee0882021-12-02T15:06:16ZTissue alkalosis in cold-ischemia time10.1038/s41598-017-11284-z2045-2322https://doaj.org/article/2c20798e849a4c2e999d60c1a07ee0882017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-11284-zhttps://doaj.org/toc/2045-2322Abstract The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.V. DenninghoffE. H. R. OlivieriC. FresnoA. UcedaL. MotaA. P. SuenagaD. M. CarraroV. R. MartinsA. AvagninaF. A. SoaresA. H. J. Fróes Marques CamposNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
V. Denninghoff
E. H. R. Olivieri
C. Fresno
A. Uceda
L. Mota
A. P. Suenaga
D. M. Carraro
V. R. Martins
A. Avagnina
F. A. Soares
A. H. J. Fróes Marques Campos
Tissue alkalosis in cold-ischemia time
description Abstract The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact of cold-ischemia on tissue pH. Here we report pH variations according to time (third-order polynomial model) in mice for liver, kidney and lung samples. Tissue alkalosis in cold-ischemia time may be an underlying mechanism of gene expression changes. Therefore, tissue-pH regulation after organ removal may minimize biological stress in human tissue samples.
format article
author V. Denninghoff
E. H. R. Olivieri
C. Fresno
A. Uceda
L. Mota
A. P. Suenaga
D. M. Carraro
V. R. Martins
A. Avagnina
F. A. Soares
A. H. J. Fróes Marques Campos
author_facet V. Denninghoff
E. H. R. Olivieri
C. Fresno
A. Uceda
L. Mota
A. P. Suenaga
D. M. Carraro
V. R. Martins
A. Avagnina
F. A. Soares
A. H. J. Fróes Marques Campos
author_sort V. Denninghoff
title Tissue alkalosis in cold-ischemia time
title_short Tissue alkalosis in cold-ischemia time
title_full Tissue alkalosis in cold-ischemia time
title_fullStr Tissue alkalosis in cold-ischemia time
title_full_unstemmed Tissue alkalosis in cold-ischemia time
title_sort tissue alkalosis in cold-ischemia time
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2c20798e849a4c2e999d60c1a07ee088
work_keys_str_mv AT vdenninghoff tissuealkalosisincoldischemiatime
AT ehrolivieri tissuealkalosisincoldischemiatime
AT cfresno tissuealkalosisincoldischemiatime
AT auceda tissuealkalosisincoldischemiatime
AT lmota tissuealkalosisincoldischemiatime
AT apsuenaga tissuealkalosisincoldischemiatime
AT dmcarraro tissuealkalosisincoldischemiatime
AT vrmartins tissuealkalosisincoldischemiatime
AT aavagnina tissuealkalosisincoldischemiatime
AT fasoares tissuealkalosisincoldischemiatime
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