Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism

The small GTPase Arf6 regulates intracellular transport, phosphoinositide signalling and cholesterol homeostasis. Here, Marquer et al. show that loss of Arf6 causes cholesterol accumulation in endosomes due to defects in phosphoinositide-dependent retromer-mediated trafficking of CI-M6PR and NPC2.

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Detalles Bibliográficos
Autores principales:	Catherine Marquer, Huasong Tian, Julie Yi, Jayson Bastien, Claudia Dall'Armi, YoungJoo Yang-Klingler, Bowen Zhou, Robin Barry Chan, Gilbert Di Paolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c2430c3a2ba4bf78869ca4b08f032c7
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spelling	oai:doaj.org-article:2c2430c3a2ba4bf78869ca4b08f032c72021-12-02T16:58:12ZArf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism10.1038/ncomms119192041-1723https://doaj.org/article/2c2430c3a2ba4bf78869ca4b08f032c72016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11919https://doaj.org/toc/2041-1723The small GTPase Arf6 regulates intracellular transport, phosphoinositide signalling and cholesterol homeostasis. Here, Marquer et al. show that loss of Arf6 causes cholesterol accumulation in endosomes due to defects in phosphoinositide-dependent retromer-mediated trafficking of CI-M6PR and NPC2.Catherine MarquerHuasong TianJulie YiJayson BastienClaudia Dall'ArmiYoungJoo Yang-KlinglerBowen ZhouRobin Barry ChanGilbert Di PaoloNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catherine Marquer Huasong Tian Julie Yi Jayson Bastien Claudia Dall'Armi YoungJoo Yang-Klingler Bowen Zhou Robin Barry Chan Gilbert Di Paolo Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
description	The small GTPase Arf6 regulates intracellular transport, phosphoinositide signalling and cholesterol homeostasis. Here, Marquer et al. show that loss of Arf6 causes cholesterol accumulation in endosomes due to defects in phosphoinositide-dependent retromer-mediated trafficking of CI-M6PR and NPC2.
format	article
author	Catherine Marquer Huasong Tian Julie Yi Jayson Bastien Claudia Dall'Armi YoungJoo Yang-Klingler Bowen Zhou Robin Barry Chan Gilbert Di Paolo
author_facet	Catherine Marquer Huasong Tian Julie Yi Jayson Bastien Claudia Dall'Armi YoungJoo Yang-Klingler Bowen Zhou Robin Barry Chan Gilbert Di Paolo
author_sort	Catherine Marquer
title	Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
title_short	Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
title_full	Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
title_fullStr	Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
title_full_unstemmed	Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
title_sort	arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2c2430c3a2ba4bf78869ca4b08f032c7
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Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism

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