Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

The pathways that underlie the effects of exercise on metabolism remain incompletely described. Here, the authors perform a meta-analysis of transcriptomic data from 66 published datasets of human skeletal muscle. They identify pathways selectively activated by inactivity, aerobic or resistance exer...

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Bibliographic Details
Main Authors: Nicolas J. Pillon, Brendan M. Gabriel, Lucile Dollet, Jonathon A. B. Smith, Laura Sardón Puig, Javier Botella, David J. Bishop, Anna Krook, Juleen R. Zierath
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/2c2929f8e4044f13af400f8dae2f008f
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Summary:The pathways that underlie the effects of exercise on metabolism remain incompletely described. Here, the authors perform a meta-analysis of transcriptomic data from 66 published datasets of human skeletal muscle. They identify pathways selectively activated by inactivity, aerobic or resistance exercise, and characterize NR4A3 as one of the genes responsive to inactivity.