Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

The pathways that underlie the effects of exercise on metabolism remain incompletely described. Here, the authors perform a meta-analysis of transcriptomic data from 66 published datasets of human skeletal muscle. They identify pathways selectively activated by inactivity, aerobic or resistance exer...

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Autores principales:	Nicolas J. Pillon, Brendan M. Gabriel, Lucile Dollet, Jonathon A. B. Smith, Laura Sardón Puig, Javier Botella, David J. Bishop, Anna Krook, Juleen R. Zierath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c2929f8e4044f13af400f8dae2f008f
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spelling	oai:doaj.org-article:2c2929f8e4044f13af400f8dae2f008f2021-12-02T14:40:41ZTranscriptomic profiling of skeletal muscle adaptations to exercise and inactivity10.1038/s41467-019-13869-w2041-1723https://doaj.org/article/2c2929f8e4044f13af400f8dae2f008f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13869-whttps://doaj.org/toc/2041-1723The pathways that underlie the effects of exercise on metabolism remain incompletely described. Here, the authors perform a meta-analysis of transcriptomic data from 66 published datasets of human skeletal muscle. They identify pathways selectively activated by inactivity, aerobic or resistance exercise, and characterize NR4A3 as one of the genes responsive to inactivity.Nicolas J. PillonBrendan M. GabrielLucile DolletJonathon A. B. SmithLaura Sardón PuigJavier BotellaDavid J. BishopAnna KrookJuleen R. ZierathNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas J. Pillon Brendan M. Gabriel Lucile Dollet Jonathon A. B. Smith Laura Sardón Puig Javier Botella David J. Bishop Anna Krook Juleen R. Zierath Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
description	The pathways that underlie the effects of exercise on metabolism remain incompletely described. Here, the authors perform a meta-analysis of transcriptomic data from 66 published datasets of human skeletal muscle. They identify pathways selectively activated by inactivity, aerobic or resistance exercise, and characterize NR4A3 as one of the genes responsive to inactivity.
format	article
author	Nicolas J. Pillon Brendan M. Gabriel Lucile Dollet Jonathon A. B. Smith Laura Sardón Puig Javier Botella David J. Bishop Anna Krook Juleen R. Zierath
author_facet	Nicolas J. Pillon Brendan M. Gabriel Lucile Dollet Jonathon A. B. Smith Laura Sardón Puig Javier Botella David J. Bishop Anna Krook Juleen R. Zierath
author_sort	Nicolas J. Pillon
title	Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
title_short	Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
title_full	Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
title_fullStr	Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
title_full_unstemmed	Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
title_sort	transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2c2929f8e4044f13af400f8dae2f008f
work_keys_str_mv	AT nicolasjpillon transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT brendanmgabriel transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT luciledollet transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT jonathonabsmith transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT laurasardonpuig transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT javierbotella transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT davidjbishop transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT annakrook transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity AT juleenrzierath transcriptomicprofilingofskeletalmuscleadaptationstoexerciseandinactivity
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Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

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