The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer
Ioannis A Voutsadakis1,2 1Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, ON, Canada; 2Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada Abstract: Breast cancer is the leading female cancer in terms of prevale...
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Dove Medical Press
2015
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oai:doaj.org-article:2c2b3aa47d8e4461bab26e2d7edc96c92021-12-02T03:45:48ZThe network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer1179-1314https://doaj.org/article/2c2b3aa47d8e4461bab26e2d7edc96c92015-09-01T00:00:00Zhttps://www.dovepress.com/the-network-of-pluripotency-epithelialndashmesenchymal-transition-and--peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Ioannis A Voutsadakis1,2 1Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, ON, Canada; 2Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada Abstract: Breast cancer is the leading female cancer in terms of prevalence. Progress in molecular biology has brought forward a better understanding of its pathogenesis that has led to better prognostication and treatment. Subtypes of breast cancer have been identified at the genomic level and guide therapeutic decisions based on their biology and the expected benefit from various interventions. Despite this progress, a significant percentage of patients die from their disease and further improvements are needed. The cancer stem cell theory and the epithelial–mesenchymal transition are two comparatively novel concepts that have been introduced in the area of cancer research and are actively investigated. Both processes have their physiologic roots in normal development and common mediators have begun to surface. This review discusses the associations of these networks as a prognostic framework in breast cancer. Keywords: stem cells, epithelial-to-mesenchymal transition, mesenchymal-to-epithelial transitionVoutsadakis IADove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 303-319 (2015) |
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DOAJ |
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EN |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Voutsadakis IA The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
| description |
Ioannis A Voutsadakis1,2 1Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste Marie, ON, Canada; 2Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada Abstract: Breast cancer is the leading female cancer in terms of prevalence. Progress in molecular biology has brought forward a better understanding of its pathogenesis that has led to better prognostication and treatment. Subtypes of breast cancer have been identified at the genomic level and guide therapeutic decisions based on their biology and the expected benefit from various interventions. Despite this progress, a significant percentage of patients die from their disease and further improvements are needed. The cancer stem cell theory and the epithelial–mesenchymal transition are two comparatively novel concepts that have been introduced in the area of cancer research and are actively investigated. Both processes have their physiologic roots in normal development and common mediators have begun to surface. This review discusses the associations of these networks as a prognostic framework in breast cancer. Keywords: stem cells, epithelial-to-mesenchymal transition, mesenchymal-to-epithelial transition |
| format |
article |
| author |
Voutsadakis IA |
| author_facet |
Voutsadakis IA |
| author_sort |
Voutsadakis IA |
| title |
The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
| title_short |
The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
| title_full |
The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
| title_fullStr |
The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
| title_full_unstemmed |
The network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
| title_sort |
network of pluripotency, epithelial–mesenchymal transition, and prognosis of breast cancer |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/2c2b3aa47d8e4461bab26e2d7edc96c9 |
| work_keys_str_mv |
AT voutsadakisia thenetworkofpluripotencyepithelialndashmesenchymaltransitionandprognosisofbreastcancer AT voutsadakisia networkofpluripotencyepithelialndashmesenchymaltransitionandprognosisofbreastcancer |
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1718401626762379264 |