Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats

BACKGROUND AND OBJECTIVE: Genistein is a soya phytoestrogen having estrogenic effects. Phytoestrogen has been introduced as one of the elements of unproductively in some animals, but previous studies on genistein role in male reproductive system have shown contradictory results. Since no similar stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	R Ghorbani, S Ghanbari, M Khazaei, S Jalili
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	genistein phytoestrogen testosterone sperm count rat Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2c2d2146efb1416ca14f51363d6416eb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c2d2146efb1416ca14f51363d6416eb
record_format	dspace
spelling	oai:doaj.org-article:2c2d2146efb1416ca14f51363d6416eb2021-11-10T08:56:58ZGenistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats1561-41072251-7170https://doaj.org/article/2c2d2146efb1416ca14f51363d6416eb2011-11-01T00:00:00Zhttp://jbums.org/article-1-3922-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Genistein is a soya phytoestrogen having estrogenic effects. Phytoestrogen has been introduced as one of the elements of unproductively in some animals, but previous studies on genistein role in male reproductive system have shown contradictory results. Since no similar study has taken place in Iran, the present study has been designed for evaluation of genistein effects on male reproductive system.METHODS: In this experimental study, 30 male rats with 13 weeks of age and limited weight of 220 to 250 grams were selected. They were divided into six groups of 5, and different genistein doses (0, 0.5, 1, 2, 4 mg/kg) were injected subcutaneously on 14 consecutive days to male rats. After 24 hours animal were killed and then their blood testosterone, FSH (follicle-stimulating hormone), and (LH Luteinizing hormone) were measured via ELAISA method. Sperm count and viability were measured through WHO protocols. FINDINGS: There was a significant reduction in FSH plasma levels among groups that were injected low doses of genistein while by increasing the genistein dose the inhibitory effect of reducing became slower (p<0.05). There were not any significant differences between other indicators. CONCLUSION: Based on our findings, genistein has an effect on FSH level of plasma and the functioning of male reproductive system.R GhorbaniS Ghanbari,M Khazaei,S JaliliBabol University of Medical Sciencesarticlegenisteinphytoestrogentestosteronesperm countratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 6, Pp 30-36 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	genistein phytoestrogen testosterone sperm count rat Medicine R Medicine (General) R5-920
spellingShingle	genistein phytoestrogen testosterone sperm count rat Medicine R Medicine (General) R5-920 R Ghorbani S Ghanbari, M Khazaei, S Jalili Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats
description	BACKGROUND AND OBJECTIVE: Genistein is a soya phytoestrogen having estrogenic effects. Phytoestrogen has been introduced as one of the elements of unproductively in some animals, but previous studies on genistein role in male reproductive system have shown contradictory results. Since no similar study has taken place in Iran, the present study has been designed for evaluation of genistein effects on male reproductive system.METHODS: In this experimental study, 30 male rats with 13 weeks of age and limited weight of 220 to 250 grams were selected. They were divided into six groups of 5, and different genistein doses (0, 0.5, 1, 2, 4 mg/kg) were injected subcutaneously on 14 consecutive days to male rats. After 24 hours animal were killed and then their blood testosterone, FSH (follicle-stimulating hormone), and (LH Luteinizing hormone) were measured via ELAISA method. Sperm count and viability were measured through WHO protocols. FINDINGS: There was a significant reduction in FSH plasma levels among groups that were injected low doses of genistein while by increasing the genistein dose the inhibitory effect of reducing became slower (p<0.05). There were not any significant differences between other indicators. CONCLUSION: Based on our findings, genistein has an effect on FSH level of plasma and the functioning of male reproductive system.
format	article
author	R Ghorbani S Ghanbari, M Khazaei, S Jalili
author_facet	R Ghorbani S Ghanbari, M Khazaei, S Jalili
author_sort	R Ghorbani
title	Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats
title_short	Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats
title_full	Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats
title_fullStr	Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats
title_full_unstemmed	Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats
title_sort	genistein effect on sex hormones, sperm count and sperm viability in male rats
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/2c2d2146efb1416ca14f51363d6416eb
work_keys_str_mv	AT rghorbani genisteineffectonsexhormonesspermcountandspermviabilityinmalerats AT sghanbari genisteineffectonsexhormonesspermcountandspermviabilityinmalerats AT mkhazaei genisteineffectonsexhormonesspermcountandspermviabilityinmalerats AT sjalili genisteineffectonsexhormonesspermcountandspermviabilityinmalerats
_version_	1718440267924635648

Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats

Ejemplares similares