Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis

Spinal cord ischemia/reperfusion (SCI/R) injury is a devastating complication usually occurring after thoracoabdominal aortic surgery. However, it remains unsatisfactory for its intervention by using pharmacological strategies. Oxidative stress is a main pharmacological process involved in SCI/R, wh...

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Autores principales:	Feng Sun, Haiwei Zhang, Jianhui Shi, Tianwen Huang, Yansong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/2c2d71762ac24007984801f9b1c02cdb
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spelling	oai:doaj.org-article:2c2d71762ac24007984801f9b1c02cdb2021-11-08T02:35:22ZAstragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis2314-614110.1155/2021/7254708https://doaj.org/article/2c2d71762ac24007984801f9b1c02cdb2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7254708https://doaj.org/toc/2314-6141Spinal cord ischemia/reperfusion (SCI/R) injury is a devastating complication usually occurring after thoracoabdominal aortic surgery. However, it remains unsatisfactory for its intervention by using pharmacological strategies. Oxidative stress is a main pharmacological process involved in SCI/R, which will elicit downstream programmed cell death such as the novel defined necroptosis. Astragalin is a bioactive natural flavonoid with a wide spectrum of pharmacological activities. Herein, we firstly evaluated the effect of astragalin to oxidative stress as well as the possible downstream necroptosis after SCI/R in mice. Our results demonstrated that astragalin improves the ethological score and histopathological deterioration of SCI/R mice. Astragalin mitigates oxidative stress and ameliorates inflammation after SCI/R. Astragalin blocks necroptosis induced by SCI/R. That is, the amelioration of astragalin to the motoneuron injury and histopathological changes. Indicators of oxidative stress, inflammation, and necroptosis after SCI/R were significantly blocked. Summarily, we firstly illustrated the protection of astragalin against SCI/R through its blockage to the necroptosis at downstream of oxidative stress.Feng SunHaiwei ZhangJianhui ShiTianwen HuangYansong WangHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Feng Sun Haiwei Zhang Jianhui Shi Tianwen Huang Yansong Wang Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis
description	Spinal cord ischemia/reperfusion (SCI/R) injury is a devastating complication usually occurring after thoracoabdominal aortic surgery. However, it remains unsatisfactory for its intervention by using pharmacological strategies. Oxidative stress is a main pharmacological process involved in SCI/R, which will elicit downstream programmed cell death such as the novel defined necroptosis. Astragalin is a bioactive natural flavonoid with a wide spectrum of pharmacological activities. Herein, we firstly evaluated the effect of astragalin to oxidative stress as well as the possible downstream necroptosis after SCI/R in mice. Our results demonstrated that astragalin improves the ethological score and histopathological deterioration of SCI/R mice. Astragalin mitigates oxidative stress and ameliorates inflammation after SCI/R. Astragalin blocks necroptosis induced by SCI/R. That is, the amelioration of astragalin to the motoneuron injury and histopathological changes. Indicators of oxidative stress, inflammation, and necroptosis after SCI/R were significantly blocked. Summarily, we firstly illustrated the protection of astragalin against SCI/R through its blockage to the necroptosis at downstream of oxidative stress.
format	article
author	Feng Sun Haiwei Zhang Jianhui Shi Tianwen Huang Yansong Wang
author_facet	Feng Sun Haiwei Zhang Jianhui Shi Tianwen Huang Yansong Wang
author_sort	Feng Sun
title	Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis
title_short	Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis
title_full	Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis
title_fullStr	Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis
title_full_unstemmed	Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis
title_sort	astragalin protects against spinal cord ischemia reperfusion injury through attenuating oxidative stress-induced necroptosis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/2c2d71762ac24007984801f9b1c02cdb
work_keys_str_mv	AT fengsun astragalinprotectsagainstspinalcordischemiareperfusioninjurythroughattenuatingoxidativestressinducednecroptosis AT haiweizhang astragalinprotectsagainstspinalcordischemiareperfusioninjurythroughattenuatingoxidativestressinducednecroptosis AT jianhuishi astragalinprotectsagainstspinalcordischemiareperfusioninjurythroughattenuatingoxidativestressinducednecroptosis AT tianwenhuang astragalinprotectsagainstspinalcordischemiareperfusioninjurythroughattenuatingoxidativestressinducednecroptosis AT yansongwang astragalinprotectsagainstspinalcordischemiareperfusioninjurythroughattenuatingoxidativestressinducednecroptosis
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Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis

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