Ultrastructural localization of intravenously injected carbon nanohorns in tumor

Sachiko Matsumura,1 Ryota Yuge,2 Shigeo Sato,3 Akihiro Tomida,3 Toshinari Ichihashi,2 Hiroshi Irie,4 Sumio Iijima,2,5,6 Kiyotaka Shiba,1 Masako Yudasaka6 1Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; 2Smart Energy Research Laboratories, NEC Corporation, Tsukuba, Japan;...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matsumura S, Yuge R, Sato S, Tomida A, Ichihashi T, Irie H, Iijima S, Shiba K, Yudasaka M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2c2edff1399646e092b3d6f71c9dc6bd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c2edff1399646e092b3d6f71c9dc6bd
record_format	dspace
spelling	oai:doaj.org-article:2c2edff1399646e092b3d6f71c9dc6bd2021-12-02T01:50:21ZUltrastructural localization of intravenously injected carbon nanohorns in tumor1178-2013https://doaj.org/article/2c2edff1399646e092b3d6f71c9dc6bd2014-07-01T00:00:00Zhttp://www.dovepress.com/ultrastructural-localization-of-intravenously-injected-carbon-nanohorn-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Sachiko Matsumura,1 Ryota Yuge,2 Shigeo Sato,3 Akihiro Tomida,3 Toshinari Ichihashi,2 Hiroshi Irie,4 Sumio Iijima,2,5,6 Kiyotaka Shiba,1 Masako Yudasaka6 1Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; 2Smart Energy Research Laboratories, NEC Corporation, Tsukuba, Japan; 3Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan; 4Teikyo University School of Medicine, Tokyo, Japan; 5Faculty of Science and Technology, Meijo University, Tenpaku, Nagoya, Japan; 6Nanotube Research Center, National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Japan Abstract: Nanocarbons have many potential medical applications. Drug delivery, diagnostic imaging, and photohyperthermia therapy, especially in the treatment of tumors, have attracted interest. For the further advancement of these application studies, the microscopic localization of nanocarbons in tumor tissues and cells is a prerequisite. In this study, carbon nanohorns (CNHs) with sizes of about 100 nm were intravenously injected into mice having subcutaneously transplanted tumors, and the CNHs in tumor tissue were observed with optical and electron microscopy. In the tumor tissue, the CNHs were found in macrophages and endothelial cells within the blood vessels. Few CNHs were found in tumor cells or in the region away from blood vessels, suggesting that, under these study conditions, the enhanced permeability of tumor blood vessels was not effective for the movement of CNHs through the vessel walls. The CNHs in normal skin tissue were similarly observed. The extravasation of CNHs was not so obvious in tumor but was easily found in normal skin, which was probably due to their vessel wall structure difference. Proper understanding of the location of CNHs in tissues is helpful in the development of the medical uses of CNHs. Keywords: ultrastructural localization, carbon nanohorn, tumor, in vivo, extravasationMatsumura SYuge RSato STomida AIchihashi TIrie HIijima SShiba KYudasaka MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3499-3508 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Matsumura S Yuge R Sato S Tomida A Ichihashi T Irie H Iijima S Shiba K Yudasaka M Ultrastructural localization of intravenously injected carbon nanohorns in tumor
description	Sachiko Matsumura,1 Ryota Yuge,2 Shigeo Sato,3 Akihiro Tomida,3 Toshinari Ichihashi,2 Hiroshi Irie,4 Sumio Iijima,2,5,6 Kiyotaka Shiba,1 Masako Yudasaka6 1Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; 2Smart Energy Research Laboratories, NEC Corporation, Tsukuba, Japan; 3Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan; 4Teikyo University School of Medicine, Tokyo, Japan; 5Faculty of Science and Technology, Meijo University, Tenpaku, Nagoya, Japan; 6Nanotube Research Center, National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Japan Abstract: Nanocarbons have many potential medical applications. Drug delivery, diagnostic imaging, and photohyperthermia therapy, especially in the treatment of tumors, have attracted interest. For the further advancement of these application studies, the microscopic localization of nanocarbons in tumor tissues and cells is a prerequisite. In this study, carbon nanohorns (CNHs) with sizes of about 100 nm were intravenously injected into mice having subcutaneously transplanted tumors, and the CNHs in tumor tissue were observed with optical and electron microscopy. In the tumor tissue, the CNHs were found in macrophages and endothelial cells within the blood vessels. Few CNHs were found in tumor cells or in the region away from blood vessels, suggesting that, under these study conditions, the enhanced permeability of tumor blood vessels was not effective for the movement of CNHs through the vessel walls. The CNHs in normal skin tissue were similarly observed. The extravasation of CNHs was not so obvious in tumor but was easily found in normal skin, which was probably due to their vessel wall structure difference. Proper understanding of the location of CNHs in tissues is helpful in the development of the medical uses of CNHs. Keywords: ultrastructural localization, carbon nanohorn, tumor, in vivo, extravasation
format	article
author	Matsumura S Yuge R Sato S Tomida A Ichihashi T Irie H Iijima S Shiba K Yudasaka M
author_facet	Matsumura S Yuge R Sato S Tomida A Ichihashi T Irie H Iijima S Shiba K Yudasaka M
author_sort	Matsumura S
title	Ultrastructural localization of intravenously injected carbon nanohorns in tumor
title_short	Ultrastructural localization of intravenously injected carbon nanohorns in tumor
title_full	Ultrastructural localization of intravenously injected carbon nanohorns in tumor
title_fullStr	Ultrastructural localization of intravenously injected carbon nanohorns in tumor
title_full_unstemmed	Ultrastructural localization of intravenously injected carbon nanohorns in tumor
title_sort	ultrastructural localization of intravenously injected carbon nanohorns in tumor
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/2c2edff1399646e092b3d6f71c9dc6bd
work_keys_str_mv	AT matsumuras ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT yuger ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT satos ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT tomidaa ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT ichihashit ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT irieh ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT iijimas ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT shibak ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor AT yudasakam ultrastructurallocalizationofintravenouslyinjectedcarbonnanohornsintumor
_version_	1718402823793672192

Ultrastructural localization of intravenously injected carbon nanohorns in tumor

Ejemplares similares