PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumor microenvironment and that PBRM1 mutations correla...

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Autores principales:	Xian-De Liu, Wen Kong, Christine B. Peterson, Daniel J. McGrail, Anh Hoang, Xuesong Zhang, Truong Lam, Patrick G. Pilie, Haifeng Zhu, Kathryn E. Beckermann, Scott M. Haake, Sevinj Isgandrova, Margarita Martinez-Moczygemba, Nidhi Sahni, Nizar M. Tannir, Shiaw-Yih Lin, W. Kimryn Rathmell, Eric Jonasch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f
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spelling	oai:doaj.org-article:2c2ffa7605cd4f008c5d3c780840e07f2021-12-02T15:39:14ZPBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma10.1038/s41467-020-15959-62041-1723https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15959-6https://doaj.org/toc/2041-1723PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumor microenvironment and that PBRM1 mutations correlate with lack of response to checkpoint inhibitor therapy in ccRCC patients..Xian-De LiuWen KongChristine B. PetersonDaniel J. McGrailAnh HoangXuesong ZhangTruong LamPatrick G. PilieHaifeng ZhuKathryn E. BeckermannScott M. HaakeSevinj IsgandrovaMargarita Martinez-MoczygembaNidhi SahniNizar M. TannirShiaw-Yih LinW. Kimryn RathmellEric JonaschNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xian-De Liu Wen Kong Christine B. Peterson Daniel J. McGrail Anh Hoang Xuesong Zhang Truong Lam Patrick G. Pilie Haifeng Zhu Kathryn E. Beckermann Scott M. Haake Sevinj Isgandrova Margarita Martinez-Moczygemba Nidhi Sahni Nizar M. Tannir Shiaw-Yih Lin W. Kimryn Rathmell Eric Jonasch PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
description	PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumor microenvironment and that PBRM1 mutations correlate with lack of response to checkpoint inhibitor therapy in ccRCC patients..
format	article
author	Xian-De Liu Wen Kong Christine B. Peterson Daniel J. McGrail Anh Hoang Xuesong Zhang Truong Lam Patrick G. Pilie Haifeng Zhu Kathryn E. Beckermann Scott M. Haake Sevinj Isgandrova Margarita Martinez-Moczygemba Nidhi Sahni Nizar M. Tannir Shiaw-Yih Lin W. Kimryn Rathmell Eric Jonasch
author_facet	Xian-De Liu Wen Kong Christine B. Peterson Daniel J. McGrail Anh Hoang Xuesong Zhang Truong Lam Patrick G. Pilie Haifeng Zhu Kathryn E. Beckermann Scott M. Haake Sevinj Isgandrova Margarita Martinez-Moczygemba Nidhi Sahni Nizar M. Tannir Shiaw-Yih Lin W. Kimryn Rathmell Eric Jonasch
author_sort	Xian-De Liu
title	PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_short	PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_full	PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_fullStr	PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_full_unstemmed	PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_sort	pbrm1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f
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PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

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