PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumor microenvironment and that PBRM1 mutations correla...

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Autores principales: Xian-De Liu, Wen Kong, Christine B. Peterson, Daniel J. McGrail, Anh Hoang, Xuesong Zhang, Truong Lam, Patrick G. Pilie, Haifeng Zhu, Kathryn E. Beckermann, Scott M. Haake, Sevinj Isgandrova, Margarita Martinez-Moczygemba, Nidhi Sahni, Nizar M. Tannir, Shiaw-Yih Lin, W. Kimryn Rathmell, Eric Jonasch
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f
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spelling oai:doaj.org-article:2c2ffa7605cd4f008c5d3c780840e07f2021-12-02T15:39:14ZPBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma10.1038/s41467-020-15959-62041-1723https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15959-6https://doaj.org/toc/2041-1723PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumor microenvironment and that PBRM1 mutations correlate with lack of response to checkpoint inhibitor therapy in ccRCC patients..Xian-De LiuWen KongChristine B. PetersonDaniel J. McGrailAnh HoangXuesong ZhangTruong LamPatrick G. PilieHaifeng ZhuKathryn E. BeckermannScott M. HaakeSevinj IsgandrovaMargarita Martinez-MoczygembaNidhi SahniNizar M. TannirShiaw-Yih LinW. Kimryn RathmellEric JonaschNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xian-De Liu
Wen Kong
Christine B. Peterson
Daniel J. McGrail
Anh Hoang
Xuesong Zhang
Truong Lam
Patrick G. Pilie
Haifeng Zhu
Kathryn E. Beckermann
Scott M. Haake
Sevinj Isgandrova
Margarita Martinez-Moczygemba
Nidhi Sahni
Nizar M. Tannir
Shiaw-Yih Lin
W. Kimryn Rathmell
Eric Jonasch
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
description PBRM1, encoding for a subunit of the SWI/SNF complex, is the second most frequently mutated gene in clear cell renal cell carcinoma (ccRCC). Here, the authors show that PBRM1 loss reduces IFNγ-mediated signalling resulting in a less immunogenic tumor microenvironment and that PBRM1 mutations correlate with lack of response to checkpoint inhibitor therapy in ccRCC patients..
format article
author Xian-De Liu
Wen Kong
Christine B. Peterson
Daniel J. McGrail
Anh Hoang
Xuesong Zhang
Truong Lam
Patrick G. Pilie
Haifeng Zhu
Kathryn E. Beckermann
Scott M. Haake
Sevinj Isgandrova
Margarita Martinez-Moczygemba
Nidhi Sahni
Nizar M. Tannir
Shiaw-Yih Lin
W. Kimryn Rathmell
Eric Jonasch
author_facet Xian-De Liu
Wen Kong
Christine B. Peterson
Daniel J. McGrail
Anh Hoang
Xuesong Zhang
Truong Lam
Patrick G. Pilie
Haifeng Zhu
Kathryn E. Beckermann
Scott M. Haake
Sevinj Isgandrova
Margarita Martinez-Moczygemba
Nidhi Sahni
Nizar M. Tannir
Shiaw-Yih Lin
W. Kimryn Rathmell
Eric Jonasch
author_sort Xian-De Liu
title PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_short PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_full PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_fullStr PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_full_unstemmed PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
title_sort pbrm1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2c2ffa7605cd4f008c5d3c780840e07f
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