Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment

Jiulong Zhao,1,* Yangbei Zhu,1,* Changqing Ye,2,* Ying Chen,2 Shige Wang,2 Duowu Zou,3 Zhaoshen Li11Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China; 2College of Science, University of Shanghai for Science an...

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Autores principales:	Zhao J, Zhu Y, Ye C, Chen Y, Wang S, Zou D, Li Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Electrospinning chitosan chemotherapy photothermal tumor therapy tumor Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2c3592ad201849d89b4f9962c8017593
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spelling	oai:doaj.org-article:2c3592ad201849d89b4f9962c80175932021-12-02T10:04:05ZPhotothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment1178-2013https://doaj.org/article/2c3592ad201849d89b4f9962c80175932019-05-01T00:00:00Zhttps://www.dovepress.com/photothermal-transforming-agent-and-chemotherapeutic-co-loaded-electro-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jiulong Zhao,1,* Yangbei Zhu,1,* Changqing Ye,2,* Ying Chen,2 Shige Wang,2 Duowu Zou,3 Zhaoshen Li11Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China; 2College of Science, University of Shanghai for Science and Technology, Shanghai 200093, People’s Republic of China; 3Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, People’s Republic of China *These authors contributed equally to this workBackground: Photothermal and chemotherapy treatment has been frequently studied for cancer therapy; however, chemotherapy is equally toxic to both normal and cancer cells. The clinical application value of most kinds of photothermal transforming agents remains limited, due to their poor degradation and minimal accumulation in tumors.Materials and methods: We reported the synthesis of photothermal transforming agents (MoS2) and chemotherapeutic (doxorubicin, DOX) co-loaded electrospun nanofibers using blend electrospinning for the treatment of postoperative tumor recurrence.Results: Under the irradiation of an 808 nm laser, the as-prepared chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an admirable photothermal conversion capability with a photothermal conversion efficiency of 23.2%. These composite nanofibers are in vitro and in vivo biocompatible. In addition, they could control the sustained release of DOX and the generated heat can sensitize the chemotherapeutic efficacy of DOX via enhancing its release rate. Their chemo-/photothermal combined therapy efficiency was systematically studied in vitro and in vivo. Instead of circulating with the body fluid, MoS2 was trapped by the nanofibrous matrix in the tumor and so its tumor-killing ability was not compromised, thus rendering this composite nanofiber a promising alternative for future clinical translation within biomedical application fields.Conclusion: Chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an excellent photothermal conversion capability with a photothermal conversion efficiency of 23.2% and can completely inhibit the postoperative tumor reoccurrence.Keywords: electrospinning, chitosan, chemotherapy, photothermal tumor therapy, tumorZhao JZhu YYe CChen YWang SZou DLi ZDove Medical PressarticleElectrospinningchitosanchemotherapyphotothermal tumor therapytumorMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3893-3909 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electrospinning chitosan chemotherapy photothermal tumor therapy tumor Medicine (General) R5-920
spellingShingle	Electrospinning chitosan chemotherapy photothermal tumor therapy tumor Medicine (General) R5-920 Zhao J Zhu Y Ye C Chen Y Wang S Zou D Li Z Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
description	Jiulong Zhao,1,* Yangbei Zhu,1,* Changqing Ye,2,* Ying Chen,2 Shige Wang,2 Duowu Zou,3 Zhaoshen Li11Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China; 2College of Science, University of Shanghai for Science and Technology, Shanghai 200093, People’s Republic of China; 3Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, People’s Republic of China *These authors contributed equally to this workBackground: Photothermal and chemotherapy treatment has been frequently studied for cancer therapy; however, chemotherapy is equally toxic to both normal and cancer cells. The clinical application value of most kinds of photothermal transforming agents remains limited, due to their poor degradation and minimal accumulation in tumors.Materials and methods: We reported the synthesis of photothermal transforming agents (MoS2) and chemotherapeutic (doxorubicin, DOX) co-loaded electrospun nanofibers using blend electrospinning for the treatment of postoperative tumor recurrence.Results: Under the irradiation of an 808 nm laser, the as-prepared chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an admirable photothermal conversion capability with a photothermal conversion efficiency of 23.2%. These composite nanofibers are in vitro and in vivo biocompatible. In addition, they could control the sustained release of DOX and the generated heat can sensitize the chemotherapeutic efficacy of DOX via enhancing its release rate. Their chemo-/photothermal combined therapy efficiency was systematically studied in vitro and in vivo. Instead of circulating with the body fluid, MoS2 was trapped by the nanofibrous matrix in the tumor and so its tumor-killing ability was not compromised, thus rendering this composite nanofiber a promising alternative for future clinical translation within biomedical application fields.Conclusion: Chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an excellent photothermal conversion capability with a photothermal conversion efficiency of 23.2% and can completely inhibit the postoperative tumor reoccurrence.Keywords: electrospinning, chitosan, chemotherapy, photothermal tumor therapy, tumor
format	article
author	Zhao J Zhu Y Ye C Chen Y Wang S Zou D Li Z
author_facet	Zhao J Zhu Y Ye C Chen Y Wang S Zou D Li Z
author_sort	Zhao J
title	Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
title_short	Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
title_full	Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
title_fullStr	Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
title_full_unstemmed	Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
title_sort	photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2c3592ad201849d89b4f9962c8017593
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Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment

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