Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Deng-Guang Yu,1 Jie Zhou,2 Nicholas P Chatterton,3 Ying Li,1 Jing Huang,2 Xia Wang11School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China; 2School of Life Sciences, East China Normal University, Shanghai, Peop...

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Autores principales: Yu DG, Zhou J, Chatterton NP, Li Y, Huang J, Wang X
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/2c363650199842e2ba921771b9aaf040
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spelling oai:doaj.org-article:2c363650199842e2ba921771b9aaf0402021-12-02T02:42:18ZPolyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process1176-91141178-2013https://doaj.org/article/2c363650199842e2ba921771b9aaf0402012-11-01T00:00:00Zhttp://www.dovepress.com/polyacrylonitrile-nanofibers-coated-with-silver-nanoparticles-using-a--a11503https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Deng-Guang Yu,1 Jie Zhou,2 Nicholas P Chatterton,3 Ying Li,1 Jing Huang,2 Xia Wang11School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China; 2School of Life Sciences, East China Normal University, Shanghai, People's Republic of China; 3Faculty of Life Sciences, London Metropolitan University, London, United KingdomBackground: The objective of this investigation was to develop a new class of antibacterial material in the form of nanofibers coated with silver nanoparticles (AgNPs) using a modified coaxial electrospinning approach. Through manipulation of the distribution on the surface of nanofibers, the antibacterial effect of Ag can be improved substantially.Methods: Using polyacrylonitrile (PAN) as the filament-forming polymer matrix, an electrospinnable PAN solution was prepared as the core fluid. A silver nitrate (AgNO3) solution was exploited as sheath fluid to carry out the modified coaxial electrospinning process under varied sheath-to-core flow rate ratios.Results: Scanning electron microscopy and transmission electron microscopy demonstrated that the sheath AgNO3 solution can take a role in reducing the nanofibers' diameters significantly, a sheath-to-core flow rate ratio of 0.1 and 0.2 resulting in PAN nanofibers with diameters of 380 ± 110 nm and 230 ± 70 nm respectively. AgNPs are well distributed on the surface of PAN nanofibers. The antibacterial experiments demonstrated that these nanofibers show strong antimicrobial activities against Bacillus subtilis Wb800, and Escherichia coli dh5α.Conclusion: Coaxial electrospinning with AgNO3 solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. We report an example of the systematic design, preparation, and application of a novel type of antibacterial material coated with AgNPs via a modified coaxial electrospinning methodology.Keywords: antibacteria, nanofibers, nano-coating, coaxial electrospinning, Ag nanoparticlesYu DGZhou JChatterton NPLi YHuang JWang XDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5725-5732 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Yu DG
Zhou J
Chatterton NP
Li Y
Huang J
Wang X
Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
description Deng-Guang Yu,1 Jie Zhou,2 Nicholas P Chatterton,3 Ying Li,1 Jing Huang,2 Xia Wang11School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China; 2School of Life Sciences, East China Normal University, Shanghai, People's Republic of China; 3Faculty of Life Sciences, London Metropolitan University, London, United KingdomBackground: The objective of this investigation was to develop a new class of antibacterial material in the form of nanofibers coated with silver nanoparticles (AgNPs) using a modified coaxial electrospinning approach. Through manipulation of the distribution on the surface of nanofibers, the antibacterial effect of Ag can be improved substantially.Methods: Using polyacrylonitrile (PAN) as the filament-forming polymer matrix, an electrospinnable PAN solution was prepared as the core fluid. A silver nitrate (AgNO3) solution was exploited as sheath fluid to carry out the modified coaxial electrospinning process under varied sheath-to-core flow rate ratios.Results: Scanning electron microscopy and transmission electron microscopy demonstrated that the sheath AgNO3 solution can take a role in reducing the nanofibers' diameters significantly, a sheath-to-core flow rate ratio of 0.1 and 0.2 resulting in PAN nanofibers with diameters of 380 ± 110 nm and 230 ± 70 nm respectively. AgNPs are well distributed on the surface of PAN nanofibers. The antibacterial experiments demonstrated that these nanofibers show strong antimicrobial activities against Bacillus subtilis Wb800, and Escherichia coli dh5α.Conclusion: Coaxial electrospinning with AgNO3 solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. We report an example of the systematic design, preparation, and application of a novel type of antibacterial material coated with AgNPs via a modified coaxial electrospinning methodology.Keywords: antibacteria, nanofibers, nano-coating, coaxial electrospinning, Ag nanoparticles
format article
author Yu DG
Zhou J
Chatterton NP
Li Y
Huang J
Wang X
author_facet Yu DG
Zhou J
Chatterton NP
Li Y
Huang J
Wang X
author_sort Yu DG
title Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_short Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_full Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_fullStr Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_full_unstemmed Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
title_sort polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/2c363650199842e2ba921771b9aaf040
work_keys_str_mv AT yudg polyacrylonitrilenanofiberscoatedwithsilvernanoparticlesusingamodifiedcoaxialelectrospinningprocess
AT zhouj polyacrylonitrilenanofiberscoatedwithsilvernanoparticlesusingamodifiedcoaxialelectrospinningprocess
AT chattertonnp polyacrylonitrilenanofiberscoatedwithsilvernanoparticlesusingamodifiedcoaxialelectrospinningprocess
AT liy polyacrylonitrilenanofiberscoatedwithsilvernanoparticlesusingamodifiedcoaxialelectrospinningprocess
AT huangj polyacrylonitrilenanofiberscoatedwithsilvernanoparticlesusingamodifiedcoaxialelectrospinningprocess
AT wangx polyacrylonitrilenanofiberscoatedwithsilvernanoparticlesusingamodifiedcoaxialelectrospinningprocess
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