HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY

Objective: To determine the rates of HCV seroconversion in patients undergoing hemodialysis (HD) in dialysis units of tertiary care hospitals. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Dialysis units of three tertiary care hospitals, from Feb to Jul 2018....

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Autores principales:	Muhammad Asif, Muhammad Zahid, Raheel Ahmad, Zafar Mehmood, Zia -Ud- Din, Ali Muhammad
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	hcv hemodialysis seroconversion Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2c37dace04eb4ed4b71be9901694b400
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spelling	oai:doaj.org-article:2c37dace04eb4ed4b71be9901694b4002021-12-02T14:54:22ZHEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY0030-96482411-8842https://doaj.org/article/2c37dace04eb4ed4b71be9901694b4002020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5880https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the rates of HCV seroconversion in patients undergoing hemodialysis (HD) in dialysis units of tertiary care hospitals. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Dialysis units of three tertiary care hospitals, from Feb to Jul 2018. Methodology: Three hundred and sixty four (364) patients on hemodialysis for more than six months were included based on inclusion criteria. All these patients were HCV negative at the initiation of dialysis. All those patients who were HCV positive at the baseline or sero-converted within six months were excluded. Patients who became HCV positive later after six months were labeled sero-converted. Data about demographics, time since initiation of HD and time to HCV seroconversion was collected through a structured questionnaire and retrieved retrospectively from patients medical record. Descriptive statistics were used to identify rate of HCV seroconversion and binary logistic regression used to estimate its determinants. Results: Of the total, 222 (61%) were males and 142 (39%) were females. The mean age (SD) of the participants was 43.76 years ± 15.86 (Range: 14-80 years). Mean (SD) duration since initiation of HD was 26.80 ± 27.99 months. Of the total, 145 (39.8%) seroconverted whereas 219 (60.2%) remained HCV negative. The mean (SD) time taken for seroconversion was 14.84 ± 11.58 (range: 6-60 months). Duration since initiation of HD was strongly associated with seroconversion (p<0.001). Conclusion: Our hemodialysis units have very high rates of HCV seroconversion and duration since initiation of HD is significantly associated with seroconversion.Muhammad AsifMuhammad ZahidRaheel AhmadZafar MehmoodZia -Ud- DinAli MuhammadArmy Medical College RawalpindiarticlehcvhemodialysisseroconversionMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1820-1824 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hcv hemodialysis seroconversion Medicine R Medicine (General) R5-920
spellingShingle	hcv hemodialysis seroconversion Medicine R Medicine (General) R5-920 Muhammad Asif Muhammad Zahid Raheel Ahmad Zafar Mehmood Zia -Ud- Din Ali Muhammad HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY
description	Objective: To determine the rates of HCV seroconversion in patients undergoing hemodialysis (HD) in dialysis units of tertiary care hospitals. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Dialysis units of three tertiary care hospitals, from Feb to Jul 2018. Methodology: Three hundred and sixty four (364) patients on hemodialysis for more than six months were included based on inclusion criteria. All these patients were HCV negative at the initiation of dialysis. All those patients who were HCV positive at the baseline or sero-converted within six months were excluded. Patients who became HCV positive later after six months were labeled sero-converted. Data about demographics, time since initiation of HD and time to HCV seroconversion was collected through a structured questionnaire and retrieved retrospectively from patients medical record. Descriptive statistics were used to identify rate of HCV seroconversion and binary logistic regression used to estimate its determinants. Results: Of the total, 222 (61%) were males and 142 (39%) were females. The mean age (SD) of the participants was 43.76 years ± 15.86 (Range: 14-80 years). Mean (SD) duration since initiation of HD was 26.80 ± 27.99 months. Of the total, 145 (39.8%) seroconverted whereas 219 (60.2%) remained HCV negative. The mean (SD) time taken for seroconversion was 14.84 ± 11.58 (range: 6-60 months). Duration since initiation of HD was strongly associated with seroconversion (p<0.001). Conclusion: Our hemodialysis units have very high rates of HCV seroconversion and duration since initiation of HD is significantly associated with seroconversion.
format	article
author	Muhammad Asif Muhammad Zahid Raheel Ahmad Zafar Mehmood Zia -Ud- Din Ali Muhammad
author_facet	Muhammad Asif Muhammad Zahid Raheel Ahmad Zafar Mehmood Zia -Ud- Din Ali Muhammad
author_sort	Muhammad Asif
title	HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY
title_short	HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY
title_full	HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY
title_fullStr	HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY
title_full_unstemmed	HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY
title_sort	hepatitis c seroconversion rates in patients on hemodialysis in tertiary care hospitals: a multicenter cross sectional study
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/2c37dace04eb4ed4b71be9901694b400
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HEPATITIS C SEROCONVERSION RATES IN PATIENTS ON HEMODIALYSIS IN TERTIARY CARE HOSPITALS: A MULTICENTER CROSS SECTIONAL STUDY

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