Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

Neuropilin-1 (Nrp-1) is a marker for CD4 + regulatory T cells. Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand semaphorin-3A, while blockade of Nrp-1 synergises wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marine Leclerc, Elodie Voilin, Gwendoline Gros, Stéphanie Corgnac, Vincent de Montpréville, Pierre Validire, Georges Bismuth, Fathia Mami-Chouaib
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c3cddaf2f6c490e988bea7275b3ada4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c3cddaf2f6c490e988bea7275b3ada4
record_format	dspace
spelling	oai:doaj.org-article:2c3cddaf2f6c490e988bea7275b3ada42021-12-02T17:01:31ZRegulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-110.1038/s41467-019-11280-z2041-1723https://doaj.org/article/2c3cddaf2f6c490e988bea7275b3ada42019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11280-zhttps://doaj.org/toc/2041-1723Neuropilin-1 (Nrp-1) is a marker for CD4 + regulatory T cells. Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand semaphorin-3A, while blockade of Nrp-1 synergises with anti-PD-1 to promote antitumour immunity in mouse tumour models.Marine LeclercElodie VoilinGwendoline GrosStéphanie CorgnacVincent de MontprévillePierre ValidireGeorges BismuthFathia Mami-ChouaibNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marine Leclerc Elodie Voilin Gwendoline Gros Stéphanie Corgnac Vincent de Montpréville Pierre Validire Georges Bismuth Fathia Mami-Chouaib Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
description	Neuropilin-1 (Nrp-1) is a marker for CD4 + regulatory T cells. Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand semaphorin-3A, while blockade of Nrp-1 synergises with anti-PD-1 to promote antitumour immunity in mouse tumour models.
format	article
author	Marine Leclerc Elodie Voilin Gwendoline Gros Stéphanie Corgnac Vincent de Montpréville Pierre Validire Georges Bismuth Fathia Mami-Chouaib
author_facet	Marine Leclerc Elodie Voilin Gwendoline Gros Stéphanie Corgnac Vincent de Montpréville Pierre Validire Georges Bismuth Fathia Mami-Chouaib
author_sort	Marine Leclerc
title	Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
title_short	Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
title_full	Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
title_fullStr	Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
title_full_unstemmed	Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
title_sort	regulation of antitumour cd8 t-cell immunity and checkpoint blockade immunotherapy by neuropilin-1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2c3cddaf2f6c490e988bea7275b3ada4
work_keys_str_mv	AT marineleclerc regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1 AT elodievoilin regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1 AT gwendolinegros regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1 AT stephaniecorgnac regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1 AT vincentdemontpreville regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1 AT pierrevalidire regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1 AT georgesbismuth regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1 AT fathiamamichouaib regulationofantitumourcd8tcellimmunityandcheckpointblockadeimmunotherapybyneuropilin1
_version_	1718382074458537984

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

Ejemplares similares