Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with chang...

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Autores principales:	Maria Gutierrez-Arcelus, Nikola Teslovich, Alex R. Mola, Rafael B. Polidoro, Aparna Nathan, Hyun Kim, Susan Hannes, Kamil Slowikowski, Gerald F. M. Watts, Ilya Korsunsky, Michael B. Brenner, Soumya Raychaudhuri, Patrick J. Brennan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c456f6c872247e0aaea1df612dd18ae
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spelling	oai:doaj.org-article:2c456f6c872247e0aaea1df612dd18ae2021-12-02T14:38:39ZLymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions10.1038/s41467-019-08604-42041-1723https://doaj.org/article/2c456f6c872247e0aaea1df612dd18ae2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08604-4https://doaj.org/toc/2041-1723Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with changes in proliferation and effector functions.Maria Gutierrez-ArcelusNikola TeslovichAlex R. MolaRafael B. PolidoroAparna NathanHyun KimSusan HannesKamil SlowikowskiGerald F. M. WattsIlya KorsunskyMichael B. BrennerSoumya RaychaudhuriPatrick J. BrennanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Gutierrez-Arcelus Nikola Teslovich Alex R. Mola Rafael B. Polidoro Aparna Nathan Hyun Kim Susan Hannes Kamil Slowikowski Gerald F. M. Watts Ilya Korsunsky Michael B. Brenner Soumya Raychaudhuri Patrick J. Brennan Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
description	Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with changes in proliferation and effector functions.
format	article
author	Maria Gutierrez-Arcelus Nikola Teslovich Alex R. Mola Rafael B. Polidoro Aparna Nathan Hyun Kim Susan Hannes Kamil Slowikowski Gerald F. M. Watts Ilya Korsunsky Michael B. Brenner Soumya Raychaudhuri Patrick J. Brennan
author_facet	Maria Gutierrez-Arcelus Nikola Teslovich Alex R. Mola Rafael B. Polidoro Aparna Nathan Hyun Kim Susan Hannes Kamil Slowikowski Gerald F. M. Watts Ilya Korsunsky Michael B. Brenner Soumya Raychaudhuri Patrick J. Brennan
author_sort	Maria Gutierrez-Arcelus
title	Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
title_short	Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
title_full	Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
title_fullStr	Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
title_full_unstemmed	Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
title_sort	lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2c456f6c872247e0aaea1df612dd18ae
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Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

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