Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration

Cell death is a critical process in health and disease, yet available markers record later stages of cell death once a cell has already begun to decompose. Here the authors show the use of a genetically encoded calcium indicator that demarcates an irreversible stage of cell death earlier than previo...

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Autores principales:	Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominik Haddad, Zak Doric, Shijie Wang, Wiktoria Leks, Jay Mancini, Viral Oza, Ashkan Javaherian, Ken Nakamura, David Kokel, Steven Finkbeiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c47160676034ab2bc322fd5c88405c2
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spelling	oai:doaj.org-article:2c47160676034ab2bc322fd5c88405c22021-12-02T17:42:05ZGenetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration10.1038/s41467-021-25549-92041-1723https://doaj.org/article/2c47160676034ab2bc322fd5c88405c22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25549-9https://doaj.org/toc/2041-1723Cell death is a critical process in health and disease, yet available markers record later stages of cell death once a cell has already begun to decompose. Here the authors show the use of a genetically encoded calcium indicator that demarcates an irreversible stage of cell death earlier than previously possible.Jeremy W. LinsleyKevan ShahNicholas CastelloMichelle ChanDominik HaddadZak DoricShijie WangWiktoria LeksJay ManciniViral OzaAshkan JavaherianKen NakamuraDavid KokelSteven FinkbeinerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeremy W. Linsley Kevan Shah Nicholas Castello Michelle Chan Dominik Haddad Zak Doric Shijie Wang Wiktoria Leks Jay Mancini Viral Oza Ashkan Javaherian Ken Nakamura David Kokel Steven Finkbeiner Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
description	Cell death is a critical process in health and disease, yet available markers record later stages of cell death once a cell has already begun to decompose. Here the authors show the use of a genetically encoded calcium indicator that demarcates an irreversible stage of cell death earlier than previously possible.
format	article
author	Jeremy W. Linsley Kevan Shah Nicholas Castello Michelle Chan Dominik Haddad Zak Doric Shijie Wang Wiktoria Leks Jay Mancini Viral Oza Ashkan Javaherian Ken Nakamura David Kokel Steven Finkbeiner
author_facet	Jeremy W. Linsley Kevan Shah Nicholas Castello Michelle Chan Dominik Haddad Zak Doric Shijie Wang Wiktoria Leks Jay Mancini Viral Oza Ashkan Javaherian Ken Nakamura David Kokel Steven Finkbeiner
author_sort	Jeremy W. Linsley
title	Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
title_short	Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
title_full	Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
title_fullStr	Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
title_full_unstemmed	Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
title_sort	genetically encoded cell-death indicators (gedi) to detect an early irreversible commitment to neurodegeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2c47160676034ab2bc322fd5c88405c2
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Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration

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