Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

The T-box transcription factor eomesodermin (EOMES) acts both in endoderm specification as well as heart development, suggesting context-specific function. Here, the authors show that dose-controlled EOMES induction is sufficient for cardiogenic programming of human pluripotent stem cells.

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Autores principales:	Martin J. Pfeiffer, Roberto Quaranta, Ilaria Piccini, Jakob Fell, Jyoti Rao, Albrecht Röpke, Guiscard Seebohm, Boris Greber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c48ddcf599740919f56f573c1232e14
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spelling	oai:doaj.org-article:2c48ddcf599740919f56f573c1232e142021-12-02T17:32:18ZCardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES10.1038/s41467-017-02812-62041-1723https://doaj.org/article/2c48ddcf599740919f56f573c1232e142018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02812-6https://doaj.org/toc/2041-1723The T-box transcription factor eomesodermin (EOMES) acts both in endoderm specification as well as heart development, suggesting context-specific function. Here, the authors show that dose-controlled EOMES induction is sufficient for cardiogenic programming of human pluripotent stem cells.Martin J. PfeifferRoberto QuarantaIlaria PicciniJakob FellJyoti RaoAlbrecht RöpkeGuiscard SeebohmBoris GreberNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin J. Pfeiffer Roberto Quaranta Ilaria Piccini Jakob Fell Jyoti Rao Albrecht Röpke Guiscard Seebohm Boris Greber Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
description	The T-box transcription factor eomesodermin (EOMES) acts both in endoderm specification as well as heart development, suggesting context-specific function. Here, the authors show that dose-controlled EOMES induction is sufficient for cardiogenic programming of human pluripotent stem cells.
format	article
author	Martin J. Pfeiffer Roberto Quaranta Ilaria Piccini Jakob Fell Jyoti Rao Albrecht Röpke Guiscard Seebohm Boris Greber
author_facet	Martin J. Pfeiffer Roberto Quaranta Ilaria Piccini Jakob Fell Jyoti Rao Albrecht Röpke Guiscard Seebohm Boris Greber
author_sort	Martin J. Pfeiffer
title	Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
title_short	Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
title_full	Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
title_fullStr	Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
title_full_unstemmed	Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
title_sort	cardiogenic programming of human pluripotent stem cells by dose-controlled activation of eomes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2c48ddcf599740919f56f573c1232e14
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Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

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