In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis

The checkerboard broth method based on the Clinical and Laboratory Standards Institute M38-A3 document was used in this study to evaluate the in vitro activity of allicin alone and in combination with the antifungal drugs (griseofulvin, fluconazole, itraconazole and terbinafine) against Microsporum...

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Autores principales:	Ya Bin Zhou, Yuan Yuan Xiao, Jin Jing Chao, Lin Ma
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Microsporum canis tinea capitis allicin drug combination antifungal drug Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2c49706a878440cca94836b5f9dda841
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spelling	oai:doaj.org-article:2c49706a878440cca94836b5f9dda8412021-12-01T05:31:10ZIn vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis2296-858X10.3389/fmed.2021.783086https://doaj.org/article/2c49706a878440cca94836b5f9dda8412021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.783086/fullhttps://doaj.org/toc/2296-858XThe checkerboard broth method based on the Clinical and Laboratory Standards Institute M38-A3 document was used in this study to evaluate the in vitro activity of allicin alone and in combination with the antifungal drugs (griseofulvin, fluconazole, itraconazole and terbinafine) against Microsporum canis isolated from patients with tinea capitis. When allicin was used alone, only weak anti-M. canis effects were found. The MIC50, MIC90 and geometric mean (GM) of terbinafine were the lowest among the compounds tested. Synergism was observed for the combinations of allicin with itraconazole and terbinafine. Only indifference was observed for the combinations of allicin with griseofulvin and fluconazole. Our study illustrated the synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.Ya Bin ZhouYuan Yuan XiaoJin Jing ChaoLin MaFrontiers Media S.A.articleMicrosporum canistinea capitisallicindrug combinationantifungal drugMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microsporum canis tinea capitis allicin drug combination antifungal drug Medicine (General) R5-920
spellingShingle	Microsporum canis tinea capitis allicin drug combination antifungal drug Medicine (General) R5-920 Ya Bin Zhou Yuan Yuan Xiao Jin Jing Chao Lin Ma In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis
description	The checkerboard broth method based on the Clinical and Laboratory Standards Institute M38-A3 document was used in this study to evaluate the in vitro activity of allicin alone and in combination with the antifungal drugs (griseofulvin, fluconazole, itraconazole and terbinafine) against Microsporum canis isolated from patients with tinea capitis. When allicin was used alone, only weak anti-M. canis effects were found. The MIC50, MIC90 and geometric mean (GM) of terbinafine were the lowest among the compounds tested. Synergism was observed for the combinations of allicin with itraconazole and terbinafine. Only indifference was observed for the combinations of allicin with griseofulvin and fluconazole. Our study illustrated the synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to M. canis.
format	article
author	Ya Bin Zhou Yuan Yuan Xiao Jin Jing Chao Lin Ma
author_facet	Ya Bin Zhou Yuan Yuan Xiao Jin Jing Chao Lin Ma
author_sort	Ya Bin Zhou
title	In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis
title_short	In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis
title_full	In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis
title_fullStr	In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis
title_full_unstemmed	In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis
title_sort	in vitro activity of allicin alone and in combination with antifungal drugs against microsporum canis isolated from patients with tinea capitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2c49706a878440cca94836b5f9dda841
work_keys_str_mv	AT yabinzhou invitroactivityofallicinaloneandincombinationwithantifungaldrugsagainstmicrosporumcanisisolatedfrompatientswithtineacapitis AT yuanyuanxiao invitroactivityofallicinaloneandincombinationwithantifungaldrugsagainstmicrosporumcanisisolatedfrompatientswithtineacapitis AT jinjingchao invitroactivityofallicinaloneandincombinationwithantifungaldrugsagainstmicrosporumcanisisolatedfrompatientswithtineacapitis AT linma invitroactivityofallicinaloneandincombinationwithantifungaldrugsagainstmicrosporumcanisisolatedfrompatientswithtineacapitis
_version_	1718405531416133632

In vitro Activity of Allicin Alone and in Combination With Antifungal Drugs Against Microsporum canis Isolated From Patients With Tinea Capitis

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