Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients

Many brain-injured patients retain large cortical islands that are intact, active and reactive but blocked in a state of low complexity, leading to unconsciousness. Here, the authors show that this loss of complexity is due to the pathological engagement of sleep-like neuronal mechanisms.

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Autores principales:	M. Rosanova, M. Fecchio, S. Casarotto, S. Sarasso, A. G. Casali, A. Pigorini, A. Comanducci, F. Seregni, G. Devalle, G. Citerio, O. Bodart, M. Boly, O. Gosseries, S. Laureys, M. Massimini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c497a066caa46c68d8081936b01511e
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spelling	oai:doaj.org-article:2c497a066caa46c68d8081936b01511e2021-12-02T17:31:12ZSleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients10.1038/s41467-018-06871-12041-1723https://doaj.org/article/2c497a066caa46c68d8081936b01511e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06871-1https://doaj.org/toc/2041-1723Many brain-injured patients retain large cortical islands that are intact, active and reactive but blocked in a state of low complexity, leading to unconsciousness. Here, the authors show that this loss of complexity is due to the pathological engagement of sleep-like neuronal mechanisms.M. RosanovaM. FecchioS. CasarottoS. SarassoA. G. CasaliA. PigoriniA. ComanducciF. SeregniG. DevalleG. CiterioO. BodartM. BolyO. GosseriesS. LaureysM. MassiminiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Rosanova M. Fecchio S. Casarotto S. Sarasso A. G. Casali A. Pigorini A. Comanducci F. Seregni G. Devalle G. Citerio O. Bodart M. Boly O. Gosseries S. Laureys M. Massimini Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
description	Many brain-injured patients retain large cortical islands that are intact, active and reactive but blocked in a state of low complexity, leading to unconsciousness. Here, the authors show that this loss of complexity is due to the pathological engagement of sleep-like neuronal mechanisms.
format	article
author	M. Rosanova M. Fecchio S. Casarotto S. Sarasso A. G. Casali A. Pigorini A. Comanducci F. Seregni G. Devalle G. Citerio O. Bodart M. Boly O. Gosseries S. Laureys M. Massimini
author_facet	M. Rosanova M. Fecchio S. Casarotto S. Sarasso A. G. Casali A. Pigorini A. Comanducci F. Seregni G. Devalle G. Citerio O. Bodart M. Boly O. Gosseries S. Laureys M. Massimini
author_sort	M. Rosanova
title	Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
title_short	Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
title_full	Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
title_fullStr	Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
title_full_unstemmed	Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
title_sort	sleep-like cortical off-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2c497a066caa46c68d8081936b01511e
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Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients

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