Platelet function is modified by common sequence variation in megakaryocyte super enhancers

Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.

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Autores principales:	Romina Petersen, John J. Lambourne, Biola M. Javierre, Luigi Grassi, Roman Kreuzhuber, Dace Ruklisa, Isabel M. Rosa, Ana R. Tomé, Heather Elding, Johanna P. van Geffen, Tao Jiang, Samantha Farrow, Jonathan Cairns, Abeer M. Al-Subaie, Sofie Ashford, Antony Attwood, Joana Batista, Heleen Bouman, Frances Burden, Fizzah A. Choudry, Laura Clarke, Paul Flicek, Stephen F. Garner, Matthias Haimel, Carly Kempster, Vasileios Ladopoulos, An-Sofie Lenaerts, Paulina M. Materek, Harriet McKinney, Stuart Meacham, Daniel Mead, Magdolna Nagy, Christopher J. Penkett, Augusto Rendon, Denis Seyres, Benjamin Sun, Salih Tuna, Marie-Elise van der Weide, Steven W. Wingett, Joost H. Martens, Oliver Stegle, Sylvia Richardson, Ludovic Vallier, David J. Roberts, Kathleen Freson, Lorenz Wernisch, Hendrik G. Stunnenberg, John Danesh, Peter Fraser, Nicole Soranzo, Adam S. Butterworth, Johan W. Heemskerk, Ernest Turro, Mikhail Spivakov, Willem H. Ouwehand, William J. Astle, Kate Downes, Myrto Kostadima, Mattia Frontini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c4a1a97d70840748bc7d87203e84d18
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spelling	oai:doaj.org-article:2c4a1a97d70840748bc7d87203e84d182021-12-02T15:38:40ZPlatelet function is modified by common sequence variation in megakaryocyte super enhancers10.1038/ncomms160582041-1723https://doaj.org/article/2c4a1a97d70840748bc7d87203e84d182017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16058https://doaj.org/toc/2041-1723Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.Romina PetersenJohn J. LambourneBiola M. JavierreLuigi GrassiRoman KreuzhuberDace RuklisaIsabel M. RosaAna R. ToméHeather EldingJohanna P. van GeffenTao JiangSamantha FarrowJonathan CairnsAbeer M. Al-SubaieSofie AshfordAntony AttwoodJoana BatistaHeleen BoumanFrances BurdenFizzah A. ChoudryLaura ClarkePaul FlicekStephen F. GarnerMatthias HaimelCarly KempsterVasileios LadopoulosAn-Sofie LenaertsPaulina M. MaterekHarriet McKinneyStuart MeachamDaniel MeadMagdolna NagyChristopher J. PenkettAugusto RendonDenis SeyresBenjamin SunSalih TunaMarie-Elise van der WeideSteven W. WingettJoost H. MartensOliver StegleSylvia RichardsonLudovic VallierDavid J. RobertsKathleen FresonLorenz WernischHendrik G. StunnenbergJohn DaneshPeter FraserNicole SoranzoAdam S. ButterworthJohan W. HeemskerkErnest TurroMikhail SpivakovWillem H. OuwehandWilliam J. AstleKate DownesMyrto KostadimaMattia FrontiniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Romina Petersen John J. Lambourne Biola M. Javierre Luigi Grassi Roman Kreuzhuber Dace Ruklisa Isabel M. Rosa Ana R. Tomé Heather Elding Johanna P. van Geffen Tao Jiang Samantha Farrow Jonathan Cairns Abeer M. Al-Subaie Sofie Ashford Antony Attwood Joana Batista Heleen Bouman Frances Burden Fizzah A. Choudry Laura Clarke Paul Flicek Stephen F. Garner Matthias Haimel Carly Kempster Vasileios Ladopoulos An-Sofie Lenaerts Paulina M. Materek Harriet McKinney Stuart Meacham Daniel Mead Magdolna Nagy Christopher J. Penkett Augusto Rendon Denis Seyres Benjamin Sun Salih Tuna Marie-Elise van der Weide Steven W. Wingett Joost H. Martens Oliver Stegle Sylvia Richardson Ludovic Vallier David J. Roberts Kathleen Freson Lorenz Wernisch Hendrik G. Stunnenberg John Danesh Peter Fraser Nicole Soranzo Adam S. Butterworth Johan W. Heemskerk Ernest Turro Mikhail Spivakov Willem H. Ouwehand William J. Astle Kate Downes Myrto Kostadima Mattia Frontini Platelet function is modified by common sequence variation in megakaryocyte super enhancers
description	Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.
format	article
author	Romina Petersen John J. Lambourne Biola M. Javierre Luigi Grassi Roman Kreuzhuber Dace Ruklisa Isabel M. Rosa Ana R. Tomé Heather Elding Johanna P. van Geffen Tao Jiang Samantha Farrow Jonathan Cairns Abeer M. Al-Subaie Sofie Ashford Antony Attwood Joana Batista Heleen Bouman Frances Burden Fizzah A. Choudry Laura Clarke Paul Flicek Stephen F. Garner Matthias Haimel Carly Kempster Vasileios Ladopoulos An-Sofie Lenaerts Paulina M. Materek Harriet McKinney Stuart Meacham Daniel Mead Magdolna Nagy Christopher J. Penkett Augusto Rendon Denis Seyres Benjamin Sun Salih Tuna Marie-Elise van der Weide Steven W. Wingett Joost H. Martens Oliver Stegle Sylvia Richardson Ludovic Vallier David J. Roberts Kathleen Freson Lorenz Wernisch Hendrik G. Stunnenberg John Danesh Peter Fraser Nicole Soranzo Adam S. Butterworth Johan W. Heemskerk Ernest Turro Mikhail Spivakov Willem H. Ouwehand William J. Astle Kate Downes Myrto Kostadima Mattia Frontini
author_facet	Romina Petersen John J. Lambourne Biola M. Javierre Luigi Grassi Roman Kreuzhuber Dace Ruklisa Isabel M. Rosa Ana R. Tomé Heather Elding Johanna P. van Geffen Tao Jiang Samantha Farrow Jonathan Cairns Abeer M. Al-Subaie Sofie Ashford Antony Attwood Joana Batista Heleen Bouman Frances Burden Fizzah A. Choudry Laura Clarke Paul Flicek Stephen F. Garner Matthias Haimel Carly Kempster Vasileios Ladopoulos An-Sofie Lenaerts Paulina M. Materek Harriet McKinney Stuart Meacham Daniel Mead Magdolna Nagy Christopher J. Penkett Augusto Rendon Denis Seyres Benjamin Sun Salih Tuna Marie-Elise van der Weide Steven W. Wingett Joost H. Martens Oliver Stegle Sylvia Richardson Ludovic Vallier David J. Roberts Kathleen Freson Lorenz Wernisch Hendrik G. Stunnenberg John Danesh Peter Fraser Nicole Soranzo Adam S. Butterworth Johan W. Heemskerk Ernest Turro Mikhail Spivakov Willem H. Ouwehand William J. Astle Kate Downes Myrto Kostadima Mattia Frontini
author_sort	Romina Petersen
title	Platelet function is modified by common sequence variation in megakaryocyte super enhancers
title_short	Platelet function is modified by common sequence variation in megakaryocyte super enhancers
title_full	Platelet function is modified by common sequence variation in megakaryocyte super enhancers
title_fullStr	Platelet function is modified by common sequence variation in megakaryocyte super enhancers
title_full_unstemmed	Platelet function is modified by common sequence variation in megakaryocyte super enhancers
title_sort	platelet function is modified by common sequence variation in megakaryocyte super enhancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2c4a1a97d70840748bc7d87203e84d18
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Platelet function is modified by common sequence variation in megakaryocyte super enhancers

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