Topical administration of adrenergic receptor pharmaceutics and nerve growth factor

Jena J SteinleDepartments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USAAbstract: Topical application of nerve growth factor (NGF) and adrenergic receptor pharmaceutics are currently in use for corneal ulce...

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Autor principal:	Jena J Steinle
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2c4cdf5096d84ba2b8ac48694f98ec89
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spelling	oai:doaj.org-article:2c4cdf5096d84ba2b8ac48694f98ec892021-12-02T07:40:17ZTopical administration of adrenergic receptor pharmaceutics and nerve growth factor1177-54671177-5483https://doaj.org/article/2c4cdf5096d84ba2b8ac48694f98ec892010-06-01T00:00:00Zhttp://www.dovepress.com/topical-administration-of-adrenergic-receptor-pharmaceutics-and-nerve--a4699https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Jena J SteinleDepartments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USAAbstract: Topical application of nerve growth factor (NGF) and adrenergic receptor pharmaceutics are currently in use for corneal ulcers and glaucoma. A recent interest in the neuroprotective abilities of NGF has led to a renewed interest in NGF as a therapeutic for retinal and choroidal diseases. NGF can promote cell proliferation through actions of the TrkA receptor or promote apoptosis through receptor p75NTR. This understanding has led to novel interest in the role of NGF for diseases of the posterior eye. The role of &beta;-adrenergic receptor agonists and antagonists for treatments of glaucoma, diabetic retinopathy, and their potential mechanisms of action, are still under investigation. This review discusses the current knowledge and applications of topical NGF and adrenergic receptor drugs for ocular disease.Keywords: NGF, &beta;-adrenergic receptor agents, &alpha;-adrenergic receptor agents, retina, cornea, glaucoma Jena J SteinleDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 605-610 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Jena J Steinle Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
description	Jena J SteinleDepartments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USAAbstract: Topical application of nerve growth factor (NGF) and adrenergic receptor pharmaceutics are currently in use for corneal ulcers and glaucoma. A recent interest in the neuroprotective abilities of NGF has led to a renewed interest in NGF as a therapeutic for retinal and choroidal diseases. NGF can promote cell proliferation through actions of the TrkA receptor or promote apoptosis through receptor p75NTR. This understanding has led to novel interest in the role of NGF for diseases of the posterior eye. The role of &beta;-adrenergic receptor agonists and antagonists for treatments of glaucoma, diabetic retinopathy, and their potential mechanisms of action, are still under investigation. This review discusses the current knowledge and applications of topical NGF and adrenergic receptor drugs for ocular disease.Keywords: NGF, &beta;-adrenergic receptor agents, &alpha;-adrenergic receptor agents, retina, cornea, glaucoma
format	article
author	Jena J Steinle
author_facet	Jena J Steinle
author_sort	Jena J Steinle
title	Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
title_short	Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
title_full	Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
title_fullStr	Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
title_full_unstemmed	Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
title_sort	topical administration of adrenergic receptor pharmaceutics and nerve growth factor
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/2c4cdf5096d84ba2b8ac48694f98ec89
work_keys_str_mv	AT jenajsteinle topicaladministrationofadrenergicreceptorpharmaceuticsandnervegrowthfactor
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Topical administration of adrenergic receptor pharmaceutics and nerve growth factor

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