A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.

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Autores principales:	Xiao-Feng Zheng, Sanket S. Acharya, Katherine N. Choe, Kumar Nikhil, Guillaume Adelmant, Shakti Ranjan Satapathy, Samanta Sharma, Keith Viccaro, Sandeep Rana, Amarnath Natarajan, Peter Sicinski, Jarrod A. Marto, Kavita Shah, Dipanjan Chowdhury
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c564c99951247baadb473f227a8cb95
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spelling	oai:doaj.org-article:2c564c99951247baadb473f227a8cb952021-12-02T15:35:57ZA mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G110.1038/s41467-019-12084-x2041-1723https://doaj.org/article/2c564c99951247baadb473f227a8cb952019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12084-xhttps://doaj.org/toc/2041-1723Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.Xiao-Feng ZhengSanket S. AcharyaKatherine N. ChoeKumar NikhilGuillaume AdelmantShakti Ranjan SatapathySamanta SharmaKeith ViccaroSandeep RanaAmarnath NatarajanPeter SicinskiJarrod A. MartoKavita ShahDipanjan ChowdhuryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao-Feng Zheng Sanket S. Acharya Katherine N. Choe Kumar Nikhil Guillaume Adelmant Shakti Ranjan Satapathy Samanta Sharma Keith Viccaro Sandeep Rana Amarnath Natarajan Peter Sicinski Jarrod A. Marto Kavita Shah Dipanjan Chowdhury A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
description	Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.
format	article
author	Xiao-Feng Zheng Sanket S. Acharya Katherine N. Choe Kumar Nikhil Guillaume Adelmant Shakti Ranjan Satapathy Samanta Sharma Keith Viccaro Sandeep Rana Amarnath Natarajan Peter Sicinski Jarrod A. Marto Kavita Shah Dipanjan Chowdhury
author_facet	Xiao-Feng Zheng Sanket S. Acharya Katherine N. Choe Kumar Nikhil Guillaume Adelmant Shakti Ranjan Satapathy Samanta Sharma Keith Viccaro Sandeep Rana Amarnath Natarajan Peter Sicinski Jarrod A. Marto Kavita Shah Dipanjan Chowdhury
author_sort	Xiao-Feng Zheng
title	A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
title_short	A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
title_full	A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
title_fullStr	A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
title_full_unstemmed	A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
title_sort	mitotic cdk5-pp4 phospho-signaling cascade primes 53bp1 for dna repair in g1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2c564c99951247baadb473f227a8cb95
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A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

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