In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification. The method introduced here includes coexpression analysis and gene importance estimation to robustly identify relevant pathways and biomarkers for...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ivan V. Ozerov, Ksenia V. Lezhnina, Evgeny Izumchenko, Artem V. Artemov, Sergey Medintsev, Quentin Vanhaelen, Alexander Aliper, Jan Vijg, Andreyan N. Osipov, Ivan Labat, Michael D. West, Anton Buzdin, Charles R. Cantor, Yuri Nikolsky, Nikolay Borisov, Irina Irincheeva, Edward Khokhlovich, David Sidransky, Miguel Luiz Camargo, Alex Zhavoronkov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c57748e19064775b999e9d5f44aa2b9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c57748e19064775b999e9d5f44aa2b9
record_format	dspace
spelling	oai:doaj.org-article:2c57748e19064775b999e9d5f44aa2b92021-12-02T14:39:52ZIn silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development10.1038/ncomms134272041-1723https://doaj.org/article/2c57748e19064775b999e9d5f44aa2b92016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13427https://doaj.org/toc/2041-1723Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification. The method introduced here includes coexpression analysis and gene importance estimation to robustly identify relevant pathways and biomarkers for patient stratification.Ivan V. OzerovKsenia V. LezhninaEvgeny IzumchenkoArtem V. ArtemovSergey MedintsevQuentin VanhaelenAlexander AliperJan VijgAndreyan N. OsipovIvan LabatMichael D. WestAnton BuzdinCharles R. CantorYuri NikolskyNikolay BorisovIrina IrincheevaEdward KhokhlovichDavid SidranskyMiguel Luiz CamargoAlex ZhavoronkovNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ivan V. Ozerov Ksenia V. Lezhnina Evgeny Izumchenko Artem V. Artemov Sergey Medintsev Quentin Vanhaelen Alexander Aliper Jan Vijg Andreyan N. Osipov Ivan Labat Michael D. West Anton Buzdin Charles R. Cantor Yuri Nikolsky Nikolay Borisov Irina Irincheeva Edward Khokhlovich David Sidransky Miguel Luiz Camargo Alex Zhavoronkov In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
description	Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification. The method introduced here includes coexpression analysis and gene importance estimation to robustly identify relevant pathways and biomarkers for patient stratification.
format	article
author	Ivan V. Ozerov Ksenia V. Lezhnina Evgeny Izumchenko Artem V. Artemov Sergey Medintsev Quentin Vanhaelen Alexander Aliper Jan Vijg Andreyan N. Osipov Ivan Labat Michael D. West Anton Buzdin Charles R. Cantor Yuri Nikolsky Nikolay Borisov Irina Irincheeva Edward Khokhlovich David Sidransky Miguel Luiz Camargo Alex Zhavoronkov
author_facet	Ivan V. Ozerov Ksenia V. Lezhnina Evgeny Izumchenko Artem V. Artemov Sergey Medintsev Quentin Vanhaelen Alexander Aliper Jan Vijg Andreyan N. Osipov Ivan Labat Michael D. West Anton Buzdin Charles R. Cantor Yuri Nikolsky Nikolay Borisov Irina Irincheeva Edward Khokhlovich David Sidransky Miguel Luiz Camargo Alex Zhavoronkov
author_sort	Ivan V. Ozerov
title	In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
title_short	In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
title_full	In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
title_fullStr	In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
title_full_unstemmed	In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development
title_sort	in silico pathway activation network decomposition analysis (ipanda) as a method for biomarker development
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2c57748e19064775b999e9d5f44aa2b9
work_keys_str_mv	AT ivanvozerov insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT kseniavlezhnina insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT evgenyizumchenko insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT artemvartemov insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT sergeymedintsev insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT quentinvanhaelen insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT alexanderaliper insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT janvijg insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT andreyannosipov insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT ivanlabat insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT michaeldwest insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT antonbuzdin insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT charlesrcantor insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT yurinikolsky insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT nikolayborisov insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT irinairincheeva insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT edwardkhokhlovich insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT davidsidransky insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT miguelluizcamargo insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment AT alexzhavoronkov insilicopathwayactivationnetworkdecompositionanalysisipandaasamethodforbiomarkerdevelopment
_version_	1718390465115455488

In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Ejemplares similares