Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
Neuropeptide Y signalling in the periphery contributes to the regulation of metabolic and energy homeostasis. Here the authors show that blocking Y1R signalling in peripheral tissues using the selective antagonist BIBO3304 ameliorates diet-induced obesity and improves whole-body glucose metabolism.
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Nature Portfolio
2021
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oai:doaj.org-article:2c59ad7667ab430db0c8a9a63837c5172021-12-02T16:57:56ZPeripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity10.1038/s41467-021-22925-32041-1723https://doaj.org/article/2c59ad7667ab430db0c8a9a63837c5172021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22925-3https://doaj.org/toc/2041-1723Neuropeptide Y signalling in the periphery contributes to the regulation of metabolic and energy homeostasis. Here the authors show that blocking Y1R signalling in peripheral tissues using the selective antagonist BIBO3304 ameliorates diet-induced obesity and improves whole-body glucose metabolism.Chenxu YanTianshu ZengKailun LeeMax NobisKim LohLuoning GouZefeng XiaZhongmin GaoMohammed BensellamWill HughesJackie LauLei ZhangChi Kin IpRonaldo EnriquezHanyu GaoQiao-Ping WangQi WuJody J. HaighD. Ross LaybuttPaul TimpsonHerbert HerzogYan-Chuan ShiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chenxu Yan Tianshu Zeng Kailun Lee Max Nobis Kim Loh Luoning Gou Zefeng Xia Zhongmin Gao Mohammed Bensellam Will Hughes Jackie Lau Lei Zhang Chi Kin Ip Ronaldo Enriquez Hanyu Gao Qiao-Ping Wang Qi Wu Jody J. Haigh D. Ross Laybutt Paul Timpson Herbert Herzog Yan-Chuan Shi Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity |
| description |
Neuropeptide Y signalling in the periphery contributes to the regulation of metabolic and energy homeostasis. Here the authors show that blocking Y1R signalling in peripheral tissues using the selective antagonist BIBO3304 ameliorates diet-induced obesity and improves whole-body glucose metabolism. |
| format |
article |
| author |
Chenxu Yan Tianshu Zeng Kailun Lee Max Nobis Kim Loh Luoning Gou Zefeng Xia Zhongmin Gao Mohammed Bensellam Will Hughes Jackie Lau Lei Zhang Chi Kin Ip Ronaldo Enriquez Hanyu Gao Qiao-Ping Wang Qi Wu Jody J. Haigh D. Ross Laybutt Paul Timpson Herbert Herzog Yan-Chuan Shi |
| author_facet |
Chenxu Yan Tianshu Zeng Kailun Lee Max Nobis Kim Loh Luoning Gou Zefeng Xia Zhongmin Gao Mohammed Bensellam Will Hughes Jackie Lau Lei Zhang Chi Kin Ip Ronaldo Enriquez Hanyu Gao Qiao-Ping Wang Qi Wu Jody J. Haigh D. Ross Laybutt Paul Timpson Herbert Herzog Yan-Chuan Shi |
| author_sort |
Chenxu Yan |
| title |
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity |
| title_short |
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity |
| title_full |
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity |
| title_fullStr |
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity |
| title_full_unstemmed |
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity |
| title_sort |
peripheral-specific y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2c59ad7667ab430db0c8a9a63837c517 |
| work_keys_str_mv |
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| _version_ |
1718382437693652992 |