Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma

Abstract The aim of this study was to evaluate the impact of lymph node status from neck dissection pathological specimens on the survival for isolated regional nodal recurrence or persistence after primary treatment of nasopharyngeal carcinoma. Through a retrospective cohort study performed in an a...

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Autores principales:	David C. M. Yeung, Zenon Yeung, Eddy W. Y. Wong, Alexander C. Vlantis, Jason Y. K. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c5a0fc274a04f55810e7f9ca803ec1e
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spelling	oai:doaj.org-article:2c5a0fc274a04f55810e7f9ca803ec1e2021-12-02T17:04:37ZNeck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma10.1038/s41598-020-62625-42045-2322https://doaj.org/article/2c5a0fc274a04f55810e7f9ca803ec1e2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-62625-4https://doaj.org/toc/2045-2322Abstract The aim of this study was to evaluate the impact of lymph node status from neck dissection pathological specimens on the survival for isolated regional nodal recurrence or persistence after primary treatment of nasopharyngeal carcinoma. Through a retrospective cohort study performed in an academic tertiary referral hospital in Hong Kong. Forty-six patients who underwent a salvage neck dissection between June 2001 and January 2013 for isolated regionally recurrent or persistent nasopharyngeal carcinoma was performed. Informed consent was waived for this retrospective study by The Joint CUHK-NTEC CREC. In the study forty-six patients had a salvage neck dissection for nodal failure with a mean age of 53 and 74% (34) were male. With a mean follow-up of 45.3 months, Overall survival, disease specific survival, loco-regional recurrence free survival, and regional recurrence free survival were 56.5%, 73.9%, 87.0%, and 91.3% respectively. For both univariate and multivariate analysis, patients with a number of positive lymph nodes more than 5 and a lymph node density more than 20% were significantly associated with poorer overall survival. Extracapsular spread and pathological cervical lymph node staging did not have an association with poorer survival. In conclusion, an absolute number of positive lymph nodes more than five and a lymph node density more than 20% were potentially useful prognostic factors affecting survival following a neck dissection for regional residual or recurrent nasopharyngeal carcinoma.David C. M. YeungZenon YeungEddy W. Y. WongAlexander C. VlantisJason Y. K. ChanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David C. M. Yeung Zenon Yeung Eddy W. Y. Wong Alexander C. Vlantis Jason Y. K. Chan Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma
description	Abstract The aim of this study was to evaluate the impact of lymph node status from neck dissection pathological specimens on the survival for isolated regional nodal recurrence or persistence after primary treatment of nasopharyngeal carcinoma. Through a retrospective cohort study performed in an academic tertiary referral hospital in Hong Kong. Forty-six patients who underwent a salvage neck dissection between June 2001 and January 2013 for isolated regionally recurrent or persistent nasopharyngeal carcinoma was performed. Informed consent was waived for this retrospective study by The Joint CUHK-NTEC CREC. In the study forty-six patients had a salvage neck dissection for nodal failure with a mean age of 53 and 74% (34) were male. With a mean follow-up of 45.3 months, Overall survival, disease specific survival, loco-regional recurrence free survival, and regional recurrence free survival were 56.5%, 73.9%, 87.0%, and 91.3% respectively. For both univariate and multivariate analysis, patients with a number of positive lymph nodes more than 5 and a lymph node density more than 20% were significantly associated with poorer overall survival. Extracapsular spread and pathological cervical lymph node staging did not have an association with poorer survival. In conclusion, an absolute number of positive lymph nodes more than five and a lymph node density more than 20% were potentially useful prognostic factors affecting survival following a neck dissection for regional residual or recurrent nasopharyngeal carcinoma.
format	article
author	David C. M. Yeung Zenon Yeung Eddy W. Y. Wong Alexander C. Vlantis Jason Y. K. Chan
author_facet	David C. M. Yeung Zenon Yeung Eddy W. Y. Wong Alexander C. Vlantis Jason Y. K. Chan
author_sort	David C. M. Yeung
title	Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma
title_short	Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma
title_full	Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma
title_fullStr	Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma
title_full_unstemmed	Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma
title_sort	neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2c5a0fc274a04f55810e7f9ca803ec1e
work_keys_str_mv	AT davidcmyeung necklymphnodestatusonsurvivalofregionallyrecurrentorpersistentnasopharyngealcarcinoma AT zenonyeung necklymphnodestatusonsurvivalofregionallyrecurrentorpersistentnasopharyngealcarcinoma AT eddywywong necklymphnodestatusonsurvivalofregionallyrecurrentorpersistentnasopharyngealcarcinoma AT alexandercvlantis necklymphnodestatusonsurvivalofregionallyrecurrentorpersistentnasopharyngealcarcinoma AT jasonykchan necklymphnodestatusonsurvivalofregionallyrecurrentorpersistentnasopharyngealcarcinoma
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Neck lymph node status on survival of regionally recurrent or persistent nasopharyngeal carcinoma

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