Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure

Background: Heart failure patients with higher body mass index (BMI) exhibit better clinical outcomes. Therefore, we assessed whether the BMI can predict left ventricular ejection fraction (EF) improvement following heart failure.Methods and Results: We included 184 patients newly diagnosed with dil...

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Autores principales:	Li-fang Ye, Xue-ling Li, Shao-mei Wang, Yun-fan Wang, Ya-ru Zheng, Li-hong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	body mass index obesity left ventricular ejection fraction improvement heart failure Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/2c5db270ec5e4e6786512c8846971b66
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spelling	oai:doaj.org-article:2c5db270ec5e4e6786512c8846971b662021-12-01T22:08:31ZBody Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure2297-055X10.3389/fcvm.2021.586240https://doaj.org/article/2c5db270ec5e4e6786512c8846971b662021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.586240/fullhttps://doaj.org/toc/2297-055XBackground: Heart failure patients with higher body mass index (BMI) exhibit better clinical outcomes. Therefore, we assessed whether the BMI can predict left ventricular ejection fraction (EF) improvement following heart failure.Methods and Results: We included 184 patients newly diagnosed with dilated cardiomyopathy and reduced EF in our center and who underwent follow-up examination of EF via echocardiography after 6 months. The EF improved at 6 months in 88 participants, who were included in the heart failure with recovered EF (HFrecEF) subgroup. Patients in whom the EF remained reduced were included in the heart failure with persistently reduced EF (persistent HFrEF) subgroup. Our analyses revealed that EF increase correlated with age (r = −0.254, P = 0.001), left ventricular diastolic dimension (LVDD; r = −0.210, P = 0.004), diabetes (P = 0.034), brain natriuretic peptide (r = −0.199, P = 0.007), and BMI grade (P = 0.000). BMI grade was significantly associated with elevated EF after adjustment for other variables (P = 0.001). On multivariable analysis, compared to patients with persistent HFrEF, those with HFrecEF had higher BMI [odds ratio (OR) = 2.342 per one standard deviation increase; P = 0.001] and lower LVDD (OR = 0.466 per one standard deviation increase; P = 0.001). ROC-curve analysis data showed that BMI > 22.66 kg/m2 (sensitivity 84.1%, specificity 59.4%, AUC 0.745, P = 0.000) indicate high probability of EF recovery in 6 months.Conclusions: Our data suggest that higher BMI is strongly correlated with the recovered EF and that BMI is an effective predictor of EF improvement in patients with heart failure and reduced EF.Li-fang YeLi-fang YeXue-ling LiXue-ling LiShao-mei WangShao-mei WangYun-fan WangYun-fan WangYa-ru ZhengYa-ru ZhengLi-hong WangLi-hong WangFrontiers Media S.A.articlebody mass indexobesityleft ventricular ejection fractionimprovementheart failureDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	body mass index obesity left ventricular ejection fraction improvement heart failure Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	body mass index obesity left ventricular ejection fraction improvement heart failure Diseases of the circulatory (Cardiovascular) system RC666-701 Li-fang Ye Li-fang Ye Xue-ling Li Xue-ling Li Shao-mei Wang Shao-mei Wang Yun-fan Wang Yun-fan Wang Ya-ru Zheng Ya-ru Zheng Li-hong Wang Li-hong Wang Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
description	Background: Heart failure patients with higher body mass index (BMI) exhibit better clinical outcomes. Therefore, we assessed whether the BMI can predict left ventricular ejection fraction (EF) improvement following heart failure.Methods and Results: We included 184 patients newly diagnosed with dilated cardiomyopathy and reduced EF in our center and who underwent follow-up examination of EF via echocardiography after 6 months. The EF improved at 6 months in 88 participants, who were included in the heart failure with recovered EF (HFrecEF) subgroup. Patients in whom the EF remained reduced were included in the heart failure with persistently reduced EF (persistent HFrEF) subgroup. Our analyses revealed that EF increase correlated with age (r = −0.254, P = 0.001), left ventricular diastolic dimension (LVDD; r = −0.210, P = 0.004), diabetes (P = 0.034), brain natriuretic peptide (r = −0.199, P = 0.007), and BMI grade (P = 0.000). BMI grade was significantly associated with elevated EF after adjustment for other variables (P = 0.001). On multivariable analysis, compared to patients with persistent HFrEF, those with HFrecEF had higher BMI [odds ratio (OR) = 2.342 per one standard deviation increase; P = 0.001] and lower LVDD (OR = 0.466 per one standard deviation increase; P = 0.001). ROC-curve analysis data showed that BMI > 22.66 kg/m2 (sensitivity 84.1%, specificity 59.4%, AUC 0.745, P = 0.000) indicate high probability of EF recovery in 6 months.Conclusions: Our data suggest that higher BMI is strongly correlated with the recovered EF and that BMI is an effective predictor of EF improvement in patients with heart failure and reduced EF.
format	article
author	Li-fang Ye Li-fang Ye Xue-ling Li Xue-ling Li Shao-mei Wang Shao-mei Wang Yun-fan Wang Yun-fan Wang Ya-ru Zheng Ya-ru Zheng Li-hong Wang Li-hong Wang
author_facet	Li-fang Ye Li-fang Ye Xue-ling Li Xue-ling Li Shao-mei Wang Shao-mei Wang Yun-fan Wang Yun-fan Wang Ya-ru Zheng Ya-ru Zheng Li-hong Wang Li-hong Wang
author_sort	Li-fang Ye
title	Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
title_short	Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
title_full	Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
title_fullStr	Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
title_full_unstemmed	Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure
title_sort	body mass index: an effective predictor of ejection fraction improvement in heart failure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2c5db270ec5e4e6786512c8846971b66
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Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure

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