The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives

Diabetes is a complex metabolic disorder affecting the glucose status of the human body. Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical relationship between diabetes and atherosclerotic cardiovascular disease is well established. This makes therapeutic...

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Autores principales:	Sotirios Tsalamandris, Alexios S Antonopoulos, Evangelos Oikonomou, George-Aggelos Papamikroulis, Georgia Vogiatzi, Spyridon Papaioannou, Spyros Deftereos, Dimitris Tousoulis
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/2c602cd4bda54df397689932cce1b7e1
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spelling	oai:doaj.org-article:2c602cd4bda54df397689932cce1b7e12021-12-04T16:01:21ZThe Role of Inflammation in Diabetes: Current Concepts and Future Perspectives10.15420/ecr.2018.33.11758-37641758-3756https://doaj.org/article/2c602cd4bda54df397689932cce1b7e12019-01-01T00:00:00Zhttps://www.ecrjournal.com/articles/role-inflammation-diabetes-current-concepts-and-future-perspectiveshttps://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Diabetes is a complex metabolic disorder affecting the glucose status of the human body. Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical relationship between diabetes and atherosclerotic cardiovascular disease is well established. This makes therapeutic approaches that simultaneously target diabetes and atherosclerotic disease an attractive area for research. The majority of people with diabetes fall into two broad pathogenetic categories, type 1 or type 2 diabetes. The role of obesity, adipose tissue, gut microbiota and pancreatic beta cell function in diabetes are under intensive scrutiny with several clinical trials to have been completed while more are in development. The emerging role of inflammation in both type 1 and type 2 diabetes (T1D and T1D) pathophysiology and associated metabolic disorders, has generated increasing interest in targeting inflammation to improve prevention and control of the disease. After an extensive review of the possible mechanisms that drive the metabolic pattern in T1D and T2D and the inflammatory pathways that are involved, it becomes ever clearer that future research should focus on a model of combined suppression for various inflammatory response pathways.Sotirios TsalamandrisAlexios S AntonopoulosEvangelos OikonomouGeorge-Aggelos PapamikroulisGeorgia VogiatziSpyridon PapaioannouSpyros DeftereosDimitris TousoulisRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 14, Iss 1, Pp 50-59 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Sotirios Tsalamandris Alexios S Antonopoulos Evangelos Oikonomou George-Aggelos Papamikroulis Georgia Vogiatzi Spyridon Papaioannou Spyros Deftereos Dimitris Tousoulis The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
description	Diabetes is a complex metabolic disorder affecting the glucose status of the human body. Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical relationship between diabetes and atherosclerotic cardiovascular disease is well established. This makes therapeutic approaches that simultaneously target diabetes and atherosclerotic disease an attractive area for research. The majority of people with diabetes fall into two broad pathogenetic categories, type 1 or type 2 diabetes. The role of obesity, adipose tissue, gut microbiota and pancreatic beta cell function in diabetes are under intensive scrutiny with several clinical trials to have been completed while more are in development. The emerging role of inflammation in both type 1 and type 2 diabetes (T1D and T1D) pathophysiology and associated metabolic disorders, has generated increasing interest in targeting inflammation to improve prevention and control of the disease. After an extensive review of the possible mechanisms that drive the metabolic pattern in T1D and T2D and the inflammatory pathways that are involved, it becomes ever clearer that future research should focus on a model of combined suppression for various inflammatory response pathways.
format	article
author	Sotirios Tsalamandris Alexios S Antonopoulos Evangelos Oikonomou George-Aggelos Papamikroulis Georgia Vogiatzi Spyridon Papaioannou Spyros Deftereos Dimitris Tousoulis
author_facet	Sotirios Tsalamandris Alexios S Antonopoulos Evangelos Oikonomou George-Aggelos Papamikroulis Georgia Vogiatzi Spyridon Papaioannou Spyros Deftereos Dimitris Tousoulis
author_sort	Sotirios Tsalamandris
title	The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
title_short	The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
title_full	The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
title_fullStr	The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
title_full_unstemmed	The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
title_sort	role of inflammation in diabetes: current concepts and future perspectives
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/2c602cd4bda54df397689932cce1b7e1
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The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives

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