Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides

Rubromycin family of natural products belongs to aromatic polyketides with diverse bioactivities, but details of their biosynthesis are limited. Here, the authors report the complete in vitro reconstitution of enzymatic formation of the spiroketal moiety of rubromycin polyketides, driven by flavin-d...

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Autores principales: Britta Frensch, Thorsten Lechtenberg, Michel Kather, Zeynep Yunt, Martin Betschart, Bernd Kammerer, Steffen Lüdeke, Michael Müller, Jörn Piel, Robin Teufel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2c66fdf660624127ac29372efbed73b9
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