Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy

Well-differentiated thyroid cancer (WDTC) is a malignant head and neck tumor with a very high incidence. Thyroidectomized WDTC patients have been referred to nuclear medicine for radioactive iodine (RAI) ablation therapy and/or annual follow-up with diagnostic whole-body imaging. Serum thyroglobulin...

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Autores principales:	Hashem O. Zahra, Gamal A. Omran, Ahmed G. Gewely, Ahmed Fathy Eldehn, Walied Abdo, Ehab Kotb Elmahallawy, Tarek M. Okda
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	WDTC thyroid carcinoma thyroglobulin anti-thyroglobulin antibody thyroid transcription factor 1 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2c6908eea1034a4d8a0be85031e35b85
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spelling	oai:doaj.org-article:2c6908eea1034a4d8a0be85031e35b852021-11-25T17:21:27ZPrognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy10.3390/diagnostics111120802075-4418https://doaj.org/article/2c6908eea1034a4d8a0be85031e35b852021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2080https://doaj.org/toc/2075-4418Well-differentiated thyroid cancer (WDTC) is a malignant head and neck tumor with a very high incidence. Thyroidectomized WDTC patients have been referred to nuclear medicine for radioactive iodine (RAI) ablation therapy and/or annual follow-up with diagnostic whole-body imaging. Serum thyroglobulin (TG) and thyroglobulin antibodies (TGAb) are biochemical tumor markers used to monitor WDTC. A global rise in the prevalence of WDTC is increasing the number of thyroidectomized patients requiring lifelong monitoring for persistent or recurrent diseases. The present study aimed to identify the most successful prognostic factors in well-defined thyroid carcinoma patients following total thyroidectomy and RAI therapy, followed by an estimation of the cutoff value of TG and TGAb. In this context, a total of 100 subjects were recruited and classified as follows: 60 thyroid carcinoma patients underwent total thyroidectomy and successful RAI therapy, while 40 normal healthy individuals matched for age, sex, and socioeconomic status constituted the control group. Interestingly, the levels of TG did not differ significantly between the relapsed and non-relapsed cases, but the levels of TGAb differed significantly between the relapsed and non-relapsed cases. Collectively, TG and TGAb are considered the most successful prognostic factors in well-defined thyroid carcinoma patients after total thyroidectomy and RAI therapy. The present study also concluded that the TGAb determination was better than that of the TG level, with a cutoff value of 10 ng/mL. These findings provide baseline information for follow-up and lifelong monitoring of thyroidectomized WDTC patients. Further research is warranted to explore more about serum TG and TGAb in thyroid carcinoma patients on a larger scale.Hashem O. ZahraGamal A. OmranAhmed G. GewelyAhmed Fathy EldehnWalied AbdoEhab Kotb ElmahallawyTarek M. OkdaMDPI AGarticleWDTCthyroid carcinomathyroglobulinanti-thyroglobulin antibodythyroid transcription factor 1Medicine (General)R5-920ENDiagnostics, Vol 11, Iss 2080, p 2080 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	WDTC thyroid carcinoma thyroglobulin anti-thyroglobulin antibody thyroid transcription factor 1 Medicine (General) R5-920
spellingShingle	WDTC thyroid carcinoma thyroglobulin anti-thyroglobulin antibody thyroid transcription factor 1 Medicine (General) R5-920 Hashem O. Zahra Gamal A. Omran Ahmed G. Gewely Ahmed Fathy Eldehn Walied Abdo Ehab Kotb Elmahallawy Tarek M. Okda Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy
description	Well-differentiated thyroid cancer (WDTC) is a malignant head and neck tumor with a very high incidence. Thyroidectomized WDTC patients have been referred to nuclear medicine for radioactive iodine (RAI) ablation therapy and/or annual follow-up with diagnostic whole-body imaging. Serum thyroglobulin (TG) and thyroglobulin antibodies (TGAb) are biochemical tumor markers used to monitor WDTC. A global rise in the prevalence of WDTC is increasing the number of thyroidectomized patients requiring lifelong monitoring for persistent or recurrent diseases. The present study aimed to identify the most successful prognostic factors in well-defined thyroid carcinoma patients following total thyroidectomy and RAI therapy, followed by an estimation of the cutoff value of TG and TGAb. In this context, a total of 100 subjects were recruited and classified as follows: 60 thyroid carcinoma patients underwent total thyroidectomy and successful RAI therapy, while 40 normal healthy individuals matched for age, sex, and socioeconomic status constituted the control group. Interestingly, the levels of TG did not differ significantly between the relapsed and non-relapsed cases, but the levels of TGAb differed significantly between the relapsed and non-relapsed cases. Collectively, TG and TGAb are considered the most successful prognostic factors in well-defined thyroid carcinoma patients after total thyroidectomy and RAI therapy. The present study also concluded that the TGAb determination was better than that of the TG level, with a cutoff value of 10 ng/mL. These findings provide baseline information for follow-up and lifelong monitoring of thyroidectomized WDTC patients. Further research is warranted to explore more about serum TG and TGAb in thyroid carcinoma patients on a larger scale.
format	article
author	Hashem O. Zahra Gamal A. Omran Ahmed G. Gewely Ahmed Fathy Eldehn Walied Abdo Ehab Kotb Elmahallawy Tarek M. Okda
author_facet	Hashem O. Zahra Gamal A. Omran Ahmed G. Gewely Ahmed Fathy Eldehn Walied Abdo Ehab Kotb Elmahallawy Tarek M. Okda
author_sort	Hashem O. Zahra
title	Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy
title_short	Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy
title_full	Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy
title_fullStr	Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy
title_full_unstemmed	Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy
title_sort	prognostic value of serum thyroglobulin and anti-thyroglobulin antibody in thyroid carcinoma patients following thyroidectomy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2c6908eea1034a4d8a0be85031e35b85
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Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy

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