Differential features of chronic cough according to etiology and the simple decision tree for predicting causes

Abstract Finding etiology of chronic cough is an essential part of treatment. Although guidelines include many laboratory tests for diagnosis, these are not possible in many primary care centers. We aimed to identify the characteristics and the differences associated with its cause to develop a clin...

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Autores principales:	Hyeon-Kyoung Koo, Won Bae, Ji-Yong Moon, Hyun Lee, Jin Woo Kim, Seung Hun Jang, Hyoung Kyu Yoon, Deog Kyeom Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c6b02a7d9d14bb793e8c82f20e0cb2e
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spelling	oai:doaj.org-article:2c6b02a7d9d14bb793e8c82f20e0cb2e2021-12-02T16:50:17ZDifferential features of chronic cough according to etiology and the simple decision tree for predicting causes10.1038/s41598-021-89741-z2045-2322https://doaj.org/article/2c6b02a7d9d14bb793e8c82f20e0cb2e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89741-zhttps://doaj.org/toc/2045-2322Abstract Finding etiology of chronic cough is an essential part of treatment. Although guidelines include many laboratory tests for diagnosis, these are not possible in many primary care centers. We aimed to identify the characteristics and the differences associated with its cause to develop a clinical prediction model. Adult subjects with chronic cough who completed both Korean version of the Leicester Cough Questionnaire (K-LCQ) and COugh Assessment Test (COAT) were enrolled. Clinical characteristics of each etiology were compared using features included in questionnaires. Decision tree models were built to classify the causes. A total of 246 subjects were included for analysis. Subjects with asthma including cough variant asthma (CVA) suffered from more severe cough in physical and psychological domains. Subjects with eosinophilic bronchitis (EB) presented less severe cough in physical domain. Those with gastro-esophageal reflux disease (GERD) displayed less severe cough in all 3 domains. In logistic regression, voice hoarseness was an independent feature of upper airway cough syndrome (UACS), whereas female sex, tiredness, and hypersensitivity to irritants were predictors of asthma/CVA; less hoarseness was a significant feature of EB, and feeling fed-up and hoarseness were less common characteristics of GERD. The decision tree was built to classify the causes and the accuracy was relatively high for both K-LCQ and COAT, except for UACS. Voice hoarseness, degree of tiredness, hypersensitivity to irritants and feeling fed-up are important features in determining the etiologies. The decision tree may further assists classifying the causes of chronic cough.Hyeon-Kyoung KooWon BaeJi-Yong MoonHyun LeeJin Woo KimSeung Hun JangHyoung Kyu YoonDeog Kyeom KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyeon-Kyoung Koo Won Bae Ji-Yong Moon Hyun Lee Jin Woo Kim Seung Hun Jang Hyoung Kyu Yoon Deog Kyeom Kim Differential features of chronic cough according to etiology and the simple decision tree for predicting causes
description	Abstract Finding etiology of chronic cough is an essential part of treatment. Although guidelines include many laboratory tests for diagnosis, these are not possible in many primary care centers. We aimed to identify the characteristics and the differences associated with its cause to develop a clinical prediction model. Adult subjects with chronic cough who completed both Korean version of the Leicester Cough Questionnaire (K-LCQ) and COugh Assessment Test (COAT) were enrolled. Clinical characteristics of each etiology were compared using features included in questionnaires. Decision tree models were built to classify the causes. A total of 246 subjects were included for analysis. Subjects with asthma including cough variant asthma (CVA) suffered from more severe cough in physical and psychological domains. Subjects with eosinophilic bronchitis (EB) presented less severe cough in physical domain. Those with gastro-esophageal reflux disease (GERD) displayed less severe cough in all 3 domains. In logistic regression, voice hoarseness was an independent feature of upper airway cough syndrome (UACS), whereas female sex, tiredness, and hypersensitivity to irritants were predictors of asthma/CVA; less hoarseness was a significant feature of EB, and feeling fed-up and hoarseness were less common characteristics of GERD. The decision tree was built to classify the causes and the accuracy was relatively high for both K-LCQ and COAT, except for UACS. Voice hoarseness, degree of tiredness, hypersensitivity to irritants and feeling fed-up are important features in determining the etiologies. The decision tree may further assists classifying the causes of chronic cough.
format	article
author	Hyeon-Kyoung Koo Won Bae Ji-Yong Moon Hyun Lee Jin Woo Kim Seung Hun Jang Hyoung Kyu Yoon Deog Kyeom Kim
author_facet	Hyeon-Kyoung Koo Won Bae Ji-Yong Moon Hyun Lee Jin Woo Kim Seung Hun Jang Hyoung Kyu Yoon Deog Kyeom Kim
author_sort	Hyeon-Kyoung Koo
title	Differential features of chronic cough according to etiology and the simple decision tree for predicting causes
title_short	Differential features of chronic cough according to etiology and the simple decision tree for predicting causes
title_full	Differential features of chronic cough according to etiology and the simple decision tree for predicting causes
title_fullStr	Differential features of chronic cough according to etiology and the simple decision tree for predicting causes
title_full_unstemmed	Differential features of chronic cough according to etiology and the simple decision tree for predicting causes
title_sort	differential features of chronic cough according to etiology and the simple decision tree for predicting causes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2c6b02a7d9d14bb793e8c82f20e0cb2e
work_keys_str_mv	AT hyeonkyoungkoo differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses AT wonbae differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses AT jiyongmoon differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses AT hyunlee differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses AT jinwookim differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses AT seunghunjang differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses AT hyoungkyuyoon differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses AT deogkyeomkim differentialfeaturesofchroniccoughaccordingtoetiologyandthesimpledecisiontreeforpredictingcauses
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Differential features of chronic cough according to etiology and the simple decision tree for predicting causes

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