The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer

Lung cancer remains one of the most frequent and the deadliest of malignant diseases throughout the world. Target and immune therapy have revolutionalized the treatment of this disease, but platinum-based chemotherapy still has a place in the treatment algorithm. The toxicity profile of cisplatin is...

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Autores principales:	Spasić Jelena, Radosavljević Davorin, Nagorni-Obradović Ljudmila
Formato:	article
Lenguaje:	EN SR
Publicado:	University of Belgrade, Medical Faculty 2021
Materias:	single nucleotide polymorphisms cisplatin toxicity Medicine R
Acceso en línea:	https://doaj.org/article/2c714b8dd9444eafb3e3c08582c8394a
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spelling	oai:doaj.org-article:2c714b8dd9444eafb3e3c08582c8394a2021-12-05T21:26:44ZThe influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer0369-15272466-552510.5937/mp72-31940https://doaj.org/article/2c714b8dd9444eafb3e3c08582c8394a2021-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2021/0369-15272102040S.pdfhttps://doaj.org/toc/0369-1527https://doaj.org/toc/2466-5525Lung cancer remains one of the most frequent and the deadliest of malignant diseases throughout the world. Target and immune therapy have revolutionalized the treatment of this disease, but platinum-based chemotherapy still has a place in the treatment algorithm. The toxicity profile of cisplatin is well known and can be a limiting factor in the adequate treatment delivery of the drug. There are important inter-individual differences in the efficacy and the toxicity of all chemotherapy drugs, which cannot be explained solely by the characteristics of the tumor. In order to define predictive factors for the occurrence of toxic effects, numerous genetic alterations have been investigated - especially single nucleotide polymorphisms (SNPs). The investigated genes are those involved in DNA repair mechanisms, signal pathways of apoptosis, DNA synthesis, transport mechanisms, but often with inconclusive and opposing results. It is clear that the effect of SNPs on the occurrence of cisplatin toxicity cannot be explained by investigating just one or several genes alone, but epigenetic interactions must be investigated, as well as interactions with outside factors. The study of SNPs is, however, a relatively simple and inexpensive method and, as such, can be used as one of the prognostic tools for everyday practice.Spasić JelenaRadosavljević DavorinNagorni-Obradović LjudmilaUniversity of Belgrade, Medical Facultyarticlesingle nucleotide polymorphismscisplatintoxicityMedicineRENSRMedicinski Podmladak, Vol 72, Iss 2, Pp 40-47 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	single nucleotide polymorphisms cisplatin toxicity Medicine R
spellingShingle	single nucleotide polymorphisms cisplatin toxicity Medicine R Spasić Jelena Radosavljević Davorin Nagorni-Obradović Ljudmila The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
description	Lung cancer remains one of the most frequent and the deadliest of malignant diseases throughout the world. Target and immune therapy have revolutionalized the treatment of this disease, but platinum-based chemotherapy still has a place in the treatment algorithm. The toxicity profile of cisplatin is well known and can be a limiting factor in the adequate treatment delivery of the drug. There are important inter-individual differences in the efficacy and the toxicity of all chemotherapy drugs, which cannot be explained solely by the characteristics of the tumor. In order to define predictive factors for the occurrence of toxic effects, numerous genetic alterations have been investigated - especially single nucleotide polymorphisms (SNPs). The investigated genes are those involved in DNA repair mechanisms, signal pathways of apoptosis, DNA synthesis, transport mechanisms, but often with inconclusive and opposing results. It is clear that the effect of SNPs on the occurrence of cisplatin toxicity cannot be explained by investigating just one or several genes alone, but epigenetic interactions must be investigated, as well as interactions with outside factors. The study of SNPs is, however, a relatively simple and inexpensive method and, as such, can be used as one of the prognostic tools for everyday practice.
format	article
author	Spasić Jelena Radosavljević Davorin Nagorni-Obradović Ljudmila
author_facet	Spasić Jelena Radosavljević Davorin Nagorni-Obradović Ljudmila
author_sort	Spasić Jelena
title	The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
title_short	The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
title_full	The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
title_fullStr	The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
title_full_unstemmed	The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
title_sort	influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer
publisher	University of Belgrade, Medical Faculty
publishDate	2021
url	https://doaj.org/article/2c714b8dd9444eafb3e3c08582c8394a
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The influence of genetic polymorphisms on the toxicity of platinum-based chemotherapy in the treatment of non-small cell lung cancer

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