Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the structural basis for isoform-specific cargo re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kate M. Smith, Sofiya Tsimbalyuk, Megan R. Edwards, Emily M. Cross, Jyoti Batra, Tatiana P. Soares da Costa, David Aragão, Christopher F. Basler, Jade K. Forwood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c7181d38279433e819e86bdf827aea6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c7181d38279433e819e86bdf827aea6
record_format	dspace
spelling	oai:doaj.org-article:2c7181d38279433e819e86bdf827aea62021-12-02T14:38:49ZStructural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses10.1038/s41467-018-05928-52041-1723https://doaj.org/article/2c7181d38279433e819e86bdf827aea62018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05928-5https://doaj.org/toc/2041-1723Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the structural basis for isoform-specific cargo recognition.Kate M. SmithSofiya TsimbalyukMegan R. EdwardsEmily M. CrossJyoti BatraTatiana P. Soares da CostaDavid AragãoChristopher F. BaslerJade K. ForwoodNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kate M. Smith Sofiya Tsimbalyuk Megan R. Edwards Emily M. Cross Jyoti Batra Tatiana P. Soares da Costa David Aragão Christopher F. Basler Jade K. Forwood Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
description	Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the structural basis for isoform-specific cargo recognition.
format	article
author	Kate M. Smith Sofiya Tsimbalyuk Megan R. Edwards Emily M. Cross Jyoti Batra Tatiana P. Soares da Costa David Aragão Christopher F. Basler Jade K. Forwood
author_facet	Kate M. Smith Sofiya Tsimbalyuk Megan R. Edwards Emily M. Cross Jyoti Batra Tatiana P. Soares da Costa David Aragão Christopher F. Basler Jade K. Forwood
author_sort	Kate M. Smith
title	Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
title_short	Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
title_full	Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
title_fullStr	Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
title_full_unstemmed	Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses
title_sort	structural basis for importin alpha 3 specificity of w proteins in hendra and nipah viruses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2c7181d38279433e819e86bdf827aea6
work_keys_str_mv	AT katemsmith structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT sofiyatsimbalyuk structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT meganredwards structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT emilymcross structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT jyotibatra structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT tatianapsoaresdacosta structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT davidaragao structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT christopherfbasler structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses AT jadekforwood structuralbasisforimportinalpha3specificityofwproteinsinhendraandnipahviruses
_version_	1718390821770756096

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

Ejemplares similares