Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex

Abstract Pain is caused by tissue injury, inflammatory disease, pathogen invasion, or neuropathy. The perception of pain is attributed to the neuronal activity in the brain. However, the dynamics of neuronal activity underlying pain perception are not fully known. Herein, we examined theta-oscillati...

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Autores principales:	Shosuke Iwamoto, Makoto Tamura, Atsushi Sasaki, Masao Nawano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c734ab3bbc04edeb81682db9c0d4a3e
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spelling	oai:doaj.org-article:2c734ab3bbc04edeb81682db9c0d4a3e2021-12-02T13:50:50ZDynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex10.1038/s41598-021-81067-02045-2322https://doaj.org/article/2c734ab3bbc04edeb81682db9c0d4a3e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81067-0https://doaj.org/toc/2045-2322Abstract Pain is caused by tissue injury, inflammatory disease, pathogen invasion, or neuropathy. The perception of pain is attributed to the neuronal activity in the brain. However, the dynamics of neuronal activity underlying pain perception are not fully known. Herein, we examined theta-oscillation dynamics of local field potentials in the primary somatosensory cortex of a mouse model of formalin-induced pain, which usually shows a bimodal behavioral response interposed between pain-free periods. We found that formalin injection exerted a reversible shift in the theta-peak frequency toward a slower frequency. This shift was observed during nociceptive phases but not during the pain-free period and was inversely correlated with instantaneous pain intensity. Furthermore, instantaneous oscillatory analysis indicated that the probability of slow theta oscillations increased during nociceptive phases with an association of augmented slow theta power. Finally, cross-frequency coupling between theta and gamma oscillations indicated that the coupling peak frequency of theta oscillations was also shifted toward slower oscillations without affecting coupling strength or gamma power. Together, these results suggest that the dynamic changes in theta oscillations in the mouse primary somatosensory cortex represent the ongoing status of pain sensation.Shosuke IwamotoMakoto TamuraAtsushi SasakiMasao NawanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shosuke Iwamoto Makoto Tamura Atsushi Sasaki Masao Nawano Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex
description	Abstract Pain is caused by tissue injury, inflammatory disease, pathogen invasion, or neuropathy. The perception of pain is attributed to the neuronal activity in the brain. However, the dynamics of neuronal activity underlying pain perception are not fully known. Herein, we examined theta-oscillation dynamics of local field potentials in the primary somatosensory cortex of a mouse model of formalin-induced pain, which usually shows a bimodal behavioral response interposed between pain-free periods. We found that formalin injection exerted a reversible shift in the theta-peak frequency toward a slower frequency. This shift was observed during nociceptive phases but not during the pain-free period and was inversely correlated with instantaneous pain intensity. Furthermore, instantaneous oscillatory analysis indicated that the probability of slow theta oscillations increased during nociceptive phases with an association of augmented slow theta power. Finally, cross-frequency coupling between theta and gamma oscillations indicated that the coupling peak frequency of theta oscillations was also shifted toward slower oscillations without affecting coupling strength or gamma power. Together, these results suggest that the dynamic changes in theta oscillations in the mouse primary somatosensory cortex represent the ongoing status of pain sensation.
format	article
author	Shosuke Iwamoto Makoto Tamura Atsushi Sasaki Masao Nawano
author_facet	Shosuke Iwamoto Makoto Tamura Atsushi Sasaki Masao Nawano
author_sort	Shosuke Iwamoto
title	Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex
title_short	Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex
title_full	Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex
title_fullStr	Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex
title_full_unstemmed	Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex
title_sort	dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2c734ab3bbc04edeb81682db9c0d4a3e
work_keys_str_mv	AT shosukeiwamoto dynamicsofneuronaloscillationsunderlyingnociceptiveresponseinthemouseprimarysomatosensorycortex AT makototamura dynamicsofneuronaloscillationsunderlyingnociceptiveresponseinthemouseprimarysomatosensorycortex AT atsushisasaki dynamicsofneuronaloscillationsunderlyingnociceptiveresponseinthemouseprimarysomatosensorycortex AT masaonawano dynamicsofneuronaloscillationsunderlyingnociceptiveresponseinthemouseprimarysomatosensorycortex
_version_	1718392428892782592

Dynamics of neuronal oscillations underlying nociceptive response in the mouse primary somatosensory cortex

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